The official cast photo released on May 3 2017 is a near exact recreation of the "Runaways" Vol. 1 comic book cover.

In the comics, in order for Nico's magic to work, Nico must make a blood sacrifice by making herself bleed by any means necessary (mostly by cutting herself). But in the show, it was change to having Nico pricking her thumb to a needle in the staff, reading her DNA in the process. This was done to avoid controversy about self-harm, which seen as a response to another teen drama, 13 Reasons Why.

Tina Minoru, the mother of Runaway Nico Minoru, appears in a prelude tie-in comic to Doctor Strange (2016) and the film itself portrayed by Linda Louise Duan.

Ariela Barer (Gert Yorkes) used a wig in every episode except for the pilot, where she just dyed her hair purple.

Leslie's church is called "The Church of Gibborim". Giborim is the Hebrew word for heroes.

The seventh TV series produced by Marvel Television to be released in 2017 and the twelfth series produced overall.

This title was rumored to become a feature film in Marvel's Phase 4 but this was opt as a series instead.

Julian McMahon previously played Marvel bad guy Victor von Doom/Doctor Doom on Fantastic Four (2005) and Fantastic 4: Rise of the Silver Surfer (2007).

The name of the coffee shop where the characters go on occasion is called "Timely Coffee". An homage to Marvel Comic's original name, Timely Comics.

In the comics, Molly is a mutant who eventually makes ties with the X-Men. In the series, the nature of her powers are left ambiguous because the film rights X-Men and mutants are owned by 21st Century Fox. However, on December 14th, 2017 while the first season was airing, Disney announced their intentions to purchase Fox's film rights which include the X-Men and Fantastic Four.

The code word that the Pride uses as an Amber Alert, 'Tsunami', and also the title of episode 8, is a reference to the Marvel Comics imprint of the same name. Tsunami was a (now defunct) line of manga-influenced comics Marvel debuted in 2003, of which Runaways was the most popular.

The Runaways was originally going to be a film in Phase One, with production began on May 2008. Brian K. Vaughn was hired to write the screenplay, Peter Sollett meant to direct the film, and Drew Pearce to write a new script. However, the project was shelved in 2013 due to the success of The Avengers, with Phase Three being the earliest time for The Runaways to become a film but it was left unannounced. The creators of Gossip Girl, Josh Schwartz and Stephanie Salvage, later made a deal with Marvel Television to turn the almost-abandoned project in to a TV series.

It's often dubbed as the 'O.C.' of the Marvel Cinematic Universe.

The working title of the show is 'Rugrats' and it pays homage to the beloved Nickelodeon series.

Keke Palmer was offered a role in the movie while Lucas Cruickshank auditioned for the role of Chase Stein.

Molly had her last name changed from Hayes to Hernandez here due to her actress being of Hispanic heritage.

Tim Pocock, who played a younger version of Victor Stein, also played a younger version of Scott Summers in X-Men Origins: Wolverine.

Coach Alphona (Chase's lacrosse coach) is named after Adrian Alphona, the artist behind the first run of the comics.

In the show, the Runaways are attending Atlas Academy. In the comics, however, it was never specified what school they were attending.

The character Vaughn is named after Runaways Brian K. Vaughn.

In the comics, original team consisted of Nico Minoru (daughter of witches), Karolina Dean (daughter of alien invaders), Molly Hayes (daughter of telepathic mutants), Gertrude Yorkes (daughter of time-travelling thieves), Chase Stein (son of mad scientist) and Alex Wilder (son of mob bosses). They are later joined by Victor Mancha (a cyborg whose father is revealed to be Ultron), Xavin (a shape shifting super-skrull in training) and Klara Prast (a mutant child bride from the 20th Century with the ability to manipulate and communicate with plants).

In episode 6 when the kids are riding in the limo, the driver is Stan Lee, Editor Emeritus of Marvel Comics who, along with Jack Kirby, created many of Marvel's initial roster of heroes. Stan has cameos in most of Marvel's movies.

In episode 9 "Doomsday", Jonah made reference to the "Do You Know Where Your Children Are?" PSA. He did this by asking the Pride where the Runaways are.

In the show, Alex gave Gert a poster for a movie theater that plays old films, with one of those films being 'Arsenic and Old Lace'. In the comics, Gert used 'Arsenic' as a codename and gave her pet dinosaur the name 'Old Lace'. This bit in the show and comics both references the movie and play 'Arsenic and Old Lace', which tells the dark humorous story of a man finding out his family has a history of insanity.

Contrary to popular belief, Karolina Dean is NOT the first LGBT character in the Marvel Cinematic Universe. Jeri Hogarth from Jessica Jones has that distinction. However, Karolina is the first major superhero in the MCU to be a member of the LGBT community.

Jonah's room strongly resembles the bedroom scene from 2001:A space odyssey.