Cast members from the original Melrose Place (1992) to appear on this follow-up included: Thomas Calabro, Heather Locklear, Josie Bissett, Laura Leighton and Daphne Zuniga.

The character of David Breck was originally intended to be David Patterson, the son of original Melrose Place (1992) character Jake Hanson and who was seen as a boy in the original series in 1997 played by actor Jer Adrianne Lelliott. However the producers decided to make the character the secret lovechild of original series character Dr. Michael Mancini instead.

Cancelled after one season.

This is the second time Katie Cassidy and Victor Webster have worked together. The first time was on Harper's Island (2009).