According to Duncan Jones, this movie is the first project he suggested to Sam Rockwell, but it was considered too big and thus Moon (2009) was made as the first movie.
The Paul Rudd and Justin Theroux roles are inspired and influenced by the Trapper John and Hawkeye Pierce characters from MASH (1970), originally played by Elliott Gould and Donald Sutherland.
David Hasselhoff is on the currency in the scene when Paul Rudd's character pays the babysitter.
Before the end credits roll, there is a dedication to the memory of the director's father David Jones (aka David Bowie) and his beloved nanny Marion Skene.
The film has been described by Duncan Jones as a "spiritual sequel" to his 2009 film Moon (2009)
It was originally conceived as a contemporary British gangster movie, then it was changed to be set in Tokyo with Ken Watanabe as Leo. It was after the success of Moon (2009) that motivated Duncan Jones to rewrite it and have it set in the future.
Clint Mansell composed the score. He was also the composer on Duncan Jones' first feature film, Moon (2009).
Easter Egg: Sam Bell from Moon can be seen in news report on telly when Cactus visits café.
In the film, the initials D (heart) R are carved on a bench. This is Duncan Jones and his wife Rodene.
Mute is dedicated to two people. David Jones and Marion Skene. David Jones is the father of director Duncan Jones and is more famously known as musician David Bowie. Skene was Duncan Jones' nanny while he was growing up.
Before Moon (2009), Duncan Jones approached Sam Rockwell for the role of Cactus Bill, but was interested in the role of Leo. Jones would write Moon (2009) specifically for Rockwell.
The knife that Paul Rudd's character uses is called a Bowie knife. Named after the 19th-century American pioneer James "Jim" Bowie for whom it was created, the director, Duncan Jones' famous singer father, David Bowie actually took his stage name from him/it.
The opening music to the film is an orchestral arrangement (by Philip Glass) of the song 'Heroes'; a song originally written and performed by David Bowie. David Bowie is Director Duncan Jones' father.
In November 2015, Duncan Jones announced that following Warcraft: The Beginning (2016), he would direct the science fiction mystery thriller Mute, starring Alexander Skarsgård and Paul Rudd.