The film set a new American box-office record for the lowest opening weekend gross for a film playing at over 2,000 theaters. It grossed $445,000 at 2,160 theaters; just two hundred six per theater. The previous record holder was Delgo (2008), which grossed just over $511,000 in 2,160 theaters.

Production completed in 2009, but the film sat on the shelf for four years, because the producer wanted to patent the film's method of providing visual cues and synchronizing house lights for a semi-interactive experience. Young viewers are encouraged to get up and dance when butterflies fly across the screen, and sit down when turtles appear.

Despite the failure of this movie, Viselman considered moving forward with two sequels to either be released theatrically or straight to DVD. Additionally, a television series was initially planned for 2015, and was moved up by at least a year to capitalize on familiarity with the new characters. But as of 2016, no further updates have come around for these resources.

Christopher Lloyd was originally considered for Bobby Wobbly.

All of the characters are loosely based on characters from the television series My Bedbugs (2004), with the exception of Woozy, who was renamed Zoozie.

The movie cost approximately $60 million to make, with $20 million spent on production and $40 million on marketing.

The film was nominated for Worst Picture and Worst Screen Ensemble at the 33rd Golden Raspberry Awards, but lost both to The Twilight Saga: Breaking Dawn - Part 2 (2012).

One of the two only theatrically released Non-Documentary film of 2012 to be Rated G by the MPAA, the other being Adventures in Zambezia (2012)

The fourth of very few live action films of the 2010s to be Rated G by the MPAA. The previous 3 (not counting documentaries) had been Ramona and Beezus (2010), Seven Days in Utopia (2011) and Alvin and the Chipmunks: Chipwrecked (2011), and the next 4 would later be A Mermaid's Tale (2017), Bernie The Dolphin (2018), Noelle (2019) and Bernie the Dolphin 2 (2019).

The movie's initial failure, Viselman stated, came down to poor marketing, not a bad product. He had twenty to thirty million dollars in marketing funds from investors in Michigan and was ready to roll the movie out, but the account froze just a week before the scheduled release, which doomed the movie. "In the end", he says, "people didn't know the movie was even playing in the theaters."