This is the only game in the whole franchise where we actually see Kane in-game. He have been the main villain in the Full-motion-videos throughout the franchise, but this is actually the first time we see a unit model and avatar of the character Kane in the actual game.

Joseph D. Kucan has played the villain 'Kane' in every single installment of the Tiberium franchise.

This is the first Command & Conquer game where you can actually train and control Visceroids. They were always a neutral non-controllable critter unit in the earlier games.