Andrea Anders previously starred on another former Friends (1994) cast member's show, Joey (2004).

Matthew Perry wrote a role for Jorge Garcia because he was a huge fan of Lost and of Garcia's character in particular.

Allison Janney and Matthew Perry previously appeared together in three episodes of The West Wing (1999) [The West Wing: Life on Mars (2003), The West Wing: Separation of Powers (2003), and The West Wing: Evidence of Things Not Seen (2003)] and one episode of Studio 60 on the Sunset Strip (2006) [Studio 60 on the Sunset Strip: The Disaster Show (2007)].

The fictional Sunshine Center in San Diego where the series is set, is based on The Forum in Los Angeles, and even has the exact capacity as The Forum (17,505).