Lip Gallagher: I believe the answer to that question, like the answer to most questions, is fuck you!

Mickey Milkovich: Alright shithead, this is like the two hundredth time I'm calling and you not picking up! I'm starting to get fucking homicidal. Call me the fuck back, Ian! I'm worried about you. I love you. Call me back.

Frank Gallagher: I'd be crying right now if I wasn't so high.

Carl Gallagher: [to Sammi] You think you scare me? Bring it, bitch!

Fiona Gallagher: What if he shows remorse?

Carl Gallagher: What's that?

Fiona Gallagher: It means you say you're sorry!

Carl Gallagher: [smirks] I'm not.

Lip Gallagher: Facts cannot be racist. Many Irish are drunks. Many French smell. Most Chinese hate children, that's why they sell them to Americans.

Carl Gallagher: [about constantly getting in trouble at school] A shrink at school says I'm one of God's mistakes.

Steve: And what exactly does "hooked up" mean?

Kevin Ball: Last time I checked, penis goes into vagina.

Kevin Ball: [to Veronica when she's about to give birth] Baby, you know what this means, right? I got a magic dick!

Sheila Jackson: They're having a party for kids across the street. No booze.

Frank Gallagher: [smiles] What's the point?

Veronica Fisher: [to Fiona] So is Lip getting serious about Mandy Skankovich?

[repeated line]

Fiona Gallagher: SHUT *UP*, Frank!

Fiona Gallagher: [to Debbie] Nobody *fucks* with the Gallaghers!

Veronica Fisher: [while giving birth] OB? I need to make an appointment with a vet. I'm havin' a damn litter!

Debbie Gallagher: That's right. NO ONE FUCKS WITH A GALLAGHER!

Mickey Milkovich: I've got an idea.

Lip Gallagher: We're not going to murder anyone.

Mickey Milkovich: I don't have any ideas.

Sheila Jackson: I will make this kitchen my bitch.

Frank Gallagher: [about his alcohol addiction] I can't handle anything up my ass without alcohol!

Frank Gallagher: [shouting while walking around the Chicago waterfront and drinking a beer] I'M *ALIVE,* MOTHERFUCKER!

Lip Gallagher: I'm not my dad. You hear me? I'm not my fucking dad!

Kevin Ball: [to Veronica] I thought that's what you ladies wanted. A shared housework, wage equality and all that Hunger Games, Lady Gaga girl power shit!

Mickey Milkovich: Fuck you, fuck you, and especially fuck you!

Fiona Gallagher: Did the two of us finish an entire gallon of box wine the other night?