Meaghan Rath, who plays Sally Malik, is the real life sister of her character's brother, Robbie Malik, played by Jesse Rath.

Although set in Boston, the show is filmed in Montreal, Quebec.

Kyle Schmid who plays the vampire Henry Durham, also had the leading role in the show Blood Ties (2007) in which he also played a vampire named Henry [Fitzroy].

Sam Witwer plays Aidan. His counterpart on the Being Human (2008) UK version, Mitchell, is played by Aidan Turner.

Both Sam Witwer and Sam Huntington have history with the character of Jimmy Olsen: Huntington played him in Superman Returns (2006) and Witwer killed him on Smallville (2001).

Josh (Sam Huntington) and Nora's (Kristen Hager) two children are played by actor Sam Huntington's real life children, Charlie and Audrey.

One of the songs heard in season 4 at the werewolf baby shower was that of the Crashtones in which Sam Witwer is the lead singer.