For the entire first season of filming, Anderson and DeVine lived in the house where their characters live in the show. They were convinced that the show was going to get cancelled, so they did it to save money.

Adam Devine and Blake Anderson say that there were giant rats living in the house used on the show.

Adam Devine, Blake Anderson, Anders Holm, and Kyle Newacheck all knew each other before the show, and had a YouTube channel called "Mail Order Comedy". They had several YouTube videos that included a web series, called "5th Year", which Comedy Central noticed, and on which this show was based. The original YouTube channel is still online.

In scenes where Adam's legs are shown, his lower legs are usually covered by socks because he has such horrific scarring on his legs after being run-over when he was little.

All the main characters on this show are named after the real-life names of their respective cast members, with the exception of Alice, Karl, and Montez.

They have often stated in interviews, that about thirty-six percent of the show was improvised.

Due to the popularity of the show, guest actors began appearing over time, including Ben Stiller and Jack Black.

There have been some references to Adam DeVine's role as Andy on Modern Family. In one episode, Adam gets a hawk called Beth, which is the name of his girlfriend. Furthermore, in the finale episode, Laura Ashley Samuels, who played his girlfriend, guest stars. Adam received immense praise for playing these two completely opposite characters at the same time.

Adam DeVine, Anders Holm, and Maribeth Monroe have all appeared on Modern Family (2009).

There is a nod to The Crow (1994) in season two, episode seven, "Teenage Mutant Ninja Roommates". Ders accuses Blake of stealing his t-shirt. It's Eric Draven Middle School, and the mascot is a crow.

In Season 3 Ep. 12 "Tele-American Horror Story" Blake asks if the man in the portrait (Robert Englund) murdered a bunch of kids in the basement. A nod to his iconic role as Freddy Krueger

A small poster for the metal band "Bleeding Through" can be spotted in the guys' cubicle at Telamericorp, near Blake's corner.

The semi-regular character Waymond (Waymond Lee) is often mocked, but he never says a word. At the end of season seven, episode ten, "Party Gawds", Waymond actually had dialogue, but was still told to shut up by the guys.