Following mixed-to-negative critical reactions and a disappointing box office in the USA, the theatrical release of the film was canceled in several overseas countries such as Belgium and The Netherlands, going straight to VOD instead.

Over the entrance to Mrs Who's house is a street-number sign with the eight hanging lopsided, forming an infinity symbol.

Oprah Winfrey got the role on the spot without auditioning. She was texting Ava DuVernay one day and DuVernay mentioned that she was developing a new "A Wrinkle in Time Adaption" and asked if she could work with her, and Oprah said "no problem".

In the book, the Murry family includes identical twin brothers Sandy and Dennys who do not appear in the movie.

In the book Meg and her family are Caucasian, and in the movie the Murry family is multiracial. This became controversial among fans of the book and its sequels, but filmmakers believed a multiracial family would be more relevant and relatable for contemporary audiences. Chris Pine has said that the multiracial family dynamic was actually one of the aspects in the script which attracted him to the project.

When Mrs. Who says, "Daaaang! Tucker, American," she is referring to Chris Tucker's popular "daaaamn" line from the Friday film series.

The cast and crew shot scenes in New Zealand for two weeks. During shooting, they were treated to a traditional Maori powhiri and karakia by the indigenous peoples of New Zealand. The cast and crew enjoyed shooting in New Zealand and frequently spoke about their love for the country.

A Wrinkle in Time (2018) marks the live action filmmaking debut of Jennifer Lee, who is best known for writing and directing films for Walt Disney Animation Studios: Wreck-It Ralph (2012), Frozen (2013), Frozen Fever (2015) and Zootopia (2016).

In 2010, it was announced that Walt Disney Pictures retained the film rights to remake the novel, following the television film version aired in 2003. Following the success of Tim Burton's Alice in Wonderland (2010), Disney announced hiring Jeff Stockwell to write the screenplay for Cary Granat and his new Bedrock Studios. Cary Granat had previously worked with Disney on the Chronicles of Narnia and Bridge to Terabithia films. The project's budget was $35 million, which the company compares to District 9 (2009) and Bridge to Terabithia (2007), both of which had less than $30 million. For reasons unknown, the project was put in development hell. It wouldn't be until four years later, on August 5, 2014, that Disney announced that Jennifer Lee would be the screenwriter for the film, who had a new take on the book and would not be working from Stockwell's draft.

First live-action movie with a nine-digit budget to be directed by a woman of color.

There is a diagram of space-time "folding" in the presentation that Mr and Mrs Murray are giving. This shows how two distant points can be brought together without having to travel the distance between them. This fold is where the "wrinkle" in the expression "a wrinkle in time" comes from.

There is a leaked video uploaded in late 2016 of the team doing the mannequin challenge during the middle of filming.

This is the first major motion picture adaptation of Madeleine L'Engle's novel since the 2003 television film adaptation.

The cover of "Sweet Dreams (Are Made of This)" played in the first promotional trailer is performed by Keeley Bumford.

This is Mindy Kaling's first live action Disney movie. She voiced Taffyta Muttonfudge in Wreck-It Ralph (2012) and Disgust in Inside Out (2015).

The second collaboration between Oprah Winfrey, David Oyelowo, André Holland, and director Ava DuVernay following Selma (2014).

The second collaboration between Reese Witherspoon and Chris Pine following This Means War (2012).

The filmmakers compared this film to the fantasy stories District 9 (2009) and Bridge to Terabithia (2007).

Amy Adams and Kevin Hart were rumored to be in this film.

Despite the title, the movie isn't about time travel, but space travel.

Chris Pine and Michael Peña worked on at least one superhero movie. Pine was in Wonder Woman (2017) and Peña was in both Ant-Man movies.

Mindy Kaling and Reese Witherspoon each appeared in an episode of The Muppets. (2015) Zach Galifianakis appeared in both The Muppets (2011) and Muppets Most Wanted (2014).

Zach Galifianakis and Michael Peña worked on a Lego movie released in 2017. Galifianakis voiced the Joker in The Lego Batman Movie (2017) and Peña voiced Kai in The Lego Ninjago Movie (2017).

Rowan Blanchard was cast against type in a small part as Veronica Kiley, the mean girl who bullied Meg and lived next door to her.

Even though this film was considered a critical and box office failure, director Ava Duvernay was chosen to direct an upcoming New Gods film for DC Comics, though she had no experience with big budget fantasy films prior to Wrinkle in Time.

Chris Pine and Michael Peña have both portrayed a character on a planet other than earth. Peña's character was on Mars (briefly) in "The Martian" and Pine has played Captain Kirk on alien planets in Star Trek movies. Both also were shown in space.

Robert Bolt had worked on the screenplay in the mid 70's.

During the Happy Medium's attempt to help Meg focus on her father's location, several different alien landscapes are shown, including one with a herd of furry, tentacled creatures. The Happy Medium exclaims, "Aw, look, it's Aunt Beast!" In the novel, a kindly, blind alien creature tends to a wounded Meg after an encounter with IT on Camazotz. Meg affectionately nicknames the alien "Aunt Beast." A four-minute deleted scene from this film shows Aunt Beast (who looks a bit like a giant Wookiee) cradling Meg while Mrs. Who translates Aunt Beast's telepathy.

Mrs. Who is known for speaking in quotes, and referencing by using the quoted's last name and country. (Although she does sometimes use her own words) This Wrinkle in Time movie has added some pop culture references. One of these is near the end, when the Mrs.' say good bye to the children. Mrs Who says " 'Tomorrow there'll be more of us.' Miranda, American." This is indeed a reference to Lin Manuel Miranda's Broadway hit "Hamilton," as a lyric from the song titled "The Story of Tonight."

Camazotz is named after a demonic god in the mythology of the Mayans.