One of the symbiotes captured by Imperium is a grey symbiote that--when it bonds to a host--manifests giant fists, a reference to Riot from the comics.
All of the main cast members, Tom Hardy (Eddie/Venom), Juno Temple (Dr. Paine), Chiwetel Ejiofor (Strickland), Rhys Ifans (Martin) and Stephen Graham (Mulligan) are British, but they are all playing Americans in this film.
Before Kelly Marcel was hired to direct the third film, Andy Serkis who directed Venom: Let There Be Carnage (2021), expressed interest in returning to direct another Venom film, and felt there was more to explore with Venom in future films before the character met Spider-Man in a future MCU/SSU crossover film, including further exploration of the Ravencroft Institute and other potential villains being held there.
The Lasher symbiote's host is Sadie Christmas, whose first name is a reference to the Lasher symbiote's host during Absolute Carnage.
Tom Holland said he and Amy Pascal had discussed him potentially reprising his role as Spider-Man in future Venom sequels.