In 2015, when Conan took his show to Havana, Cuba, it was the first time an American late night television host taped a segment there since Jack Paar with his The Jack Paar Tonight Show (1957) show in 1959.

Conan has individually interviewed the cast of The Walking Dead (2010) on his show, but never interviewed Andrew Lincoln (the lead character Rick Grimes).

This show is recorded in the same studio, in which some interior scenes for The Goonies (1985) were filmed.

The show was shortened from 1-hour to 30-minutes in January 2019.