Demetrius Shipp Jr.'s father produced "Toss It Up" for Tupac Shakur's "The Don Killuminati: The 7 Day Theory" album.

John Singleton was originally supposed to direct the film, but the studio and Singleton couldn't agree on how Tupac was to be portrayed in the film. Singleton eventually left the project completely but has since stated that he still hopes to make his own film about Tupac on his own terms some day. He was also the only director to have Afeni Shakur's full blessing to tell her son's story.

Jamal Woolard also portrayed The Notorious B.I.G. in Notorious (2009).

On Twitter, Jada Pinkett Smith stated that the film contained many inaccuracies about her relationship with Tupac Shakur and why he left for Los Angeles. Smith said that Tupac never read the poem he read to her character in the film, and she never knew it existed until it was published in his book. She also said that she never attended one of Tupac's shows at his request, and there was no backstage argument. She did, however, praise the performances of Demetrius Shipp Jr. and Kat Graham.

Benny Boom said in an interview that when he first saw a picture of Demetrius Shipp Jr., he thought it was a photo of Tupac Shakur.

Both Sean Combs and Marion 'Suge' Knight gave blessings to the film, praising their selective portrayals.

Demetrius Shipp Jr. had to lose 18 pounds to portray Tupac Shakur.

The teaser trailer was released on June 16, 2016, which would have been Tupac Shakur's 45th birthday.

Demetrius Shipp Jr. said in an interview with Snoop Dogg that it had been his dream to do what Tupac did since his father, Demetrius Shipp Sr., had been working with Death Row Records.

Released 21 years after the death of Tupac Shakur.

The movie is named after Tupac Shakur's album "All Eyez On Me", which was originally released on Feburary 13th, 1996.

Tupac Shakur's rap group, Outlawz, appear in several scenes. The two remaining members of the actual Outlawz, Rufis "Young Noble" Cooper and Malcolm "E.D.I. Mean" Greenridge appear as themselves in several scenes with Tupac throughout the film, and even have a few speaking parts. Actors portray Kastro and Napoleon. The remaining members, Hussein Fatal, Yaki Kadafi, and Mussolini, are now deceased.

This marked Lauren Cohan and Danai Gurira's first collaboration outside of The Walking Dead (2010).

The second teaser trailer came out exactly 20 years after Tupac Shakur's death.

Anthony Mackie played Tupac Shakur in Notorious (2009). Marcc Rose played Shakur in Straight Outta Compton (2015).

Kat Graham and Lauren Cohan previously worked on The Vampire Diaries (2009) together.

"The Interviewer" whom is interviewing Tupac throughout the film is modeled after real-life journalist, author, poet and activist Kevin Powell who conducted numerous interviews with Tupac throughout his career, including the ones shown in the film. The Interviewer's name is never given in the film, but it is obvious it is a strong reflection of Powell. In June 2017, Powell filed a federal lawsuit against producers of the film for copyright infringement.

In Jarrett Ellis's scene, the producers dubbed Snoop Dogg real voice over his for realism.