At the end of the party brawl between Nikki (Debbie Gibson) and Terry (Tiffany), Nikki says, "I think... we're alone now." followed by Terry saying "There doesn't seem to be anyone around." These lines are in reference to a song covered by Tiffany in her 1987 self-titled debut album. "I Think We're Alone Now" reached #1 on the Billboard charts in the U.S.

During an argument before the party brawl, Terry (Tiffany) tells Nikki (Debbie Gibson), "Only in your dreams!". This is a reference to Gibson's 1986 hit single "Only in My Dreams".

In the scene where Nikki and a group of animal rights protesters picket in front of the park ranger station, one of the protesters can be seen wearing an Electric Youth-era Debbie Gibson t-shirt and another wearing a Tiffany "Hold an Old Friends Hand" Album Tour Shirt.

In the Miami invasion scene, a python bites a blimp marked with The Asylum's logo.

The film was shot at Griffith Park and the Los Angeles County Arboretum and Botanic Garden in Los Angeles, California, which acted as a stand-in setting for Florida.

Some of the film's footage was recycled from Mega Shark vs. Crocosaurus (2010).

At 1:18:08 while Tiffany is driving down the freeway to "keep the animals away from the nuclear power plant" another car is briefly seen just in front of her. Most probably a camera crew. Beyond that there is no traffic on the freeway.

The movie is part of the notorious german "SchleFaZ" series. Thus, it was aired July 2015 on german TV station Tele5. ("SchleFaZ" is a german abbreviation, means "the worst films ever". In that series 2 hosts present the whole flick - and make fun of it throughout the movie.)