Filmed in the same back lot as Pretty Little Liars (2010) and Gilmore Girls (2000).

In the 1982 novel "Shoeless Joe" by W.P. Kinsella, the (fictional) main character, Ray Kinsella, goes on a road trip to find the (real) writer J.D. Salinger, author of "Catcher in the Rye," because Salinger had a real-life habit of using the last name "Kinsella" for his characters and Ray wants to find out why. In this show the character of Wade Kinsella is played by Wilson Bethel, whose mother, writer Joyce Maynard, had a very well-publicized relationship with Salinger.

Wilson Bethel was the first person to audition for the role of Wade. After the audition show creator Leila Gerstein and executive producer Stephanie Savage said they were "blushing" and hired him right away.

Wilson Bethel (Wade) describes co-star Rachel Bilson (Zoe) as "one of the coolest gals I've ever met in Hollywood."

Wilson Bethel (Wade) spent a week before shooting in the south to learn the southern accent.

The restaurant at which the characters in Bluebell hang out is called the "Rammer Jammer." This is a reference to a spectators' cheer yelled at University of Alabama football games when Alabama has just won or is clearly about to win. The cheer goes: "Hey, (opposing team)! Hey, (opposing team)! Hey, (opposing team)! We just beat the hell outta you! Rammer Jammer Yellow Hammer Give 'em hell, Alabama!" The term "Rammer-Jammer" came from the title of a 1920s-era student newspaper, while the Yellowhammer is the state bird of Alabama. The shooting location is the same as the one for the restaurant/bar Merlotte's in the HBO series True Blood (2008). There actually is a restaurant called "Rama Jama's" across the street from the University of Alabama football stadium in Tuscaloosa.

Wilson Bethel (Wade) was fired from The O.C. (2003) for being late; his Hart of Dixie costar Rachel Bilson (Zoe) was one of the stars of The O.C.

Since the 1950s Alabama state law has mandated that the phrase "Heart of Dixie" must appear on every Alabama car license plate, usually along with or inside a drawing of a heart.

In an interview on The View (1997), Rachel Bilson (Zoe) said that Wilson Bethell (Wade) is her biggest target for pranks because "he's so easy, he just falls for them".

The top view of the whole town is used in Pretty Little Liars (2010), Witches of East End (2013), The Carrie Diaries (2013), Gilmore Girls (2000), Riverdale (2017), Bitten (2014), and this show. The set itself is used on "Pretty Little Liars", "Gilmore Girls" and this show.

The show's creator describes it as "'The Gilmore Girls' in the South".

Rachel Bilson (Zoe) pulled a prank on co-star Wilson Bethel (Wade) after a kissing scene. She made a fake cold sore with makeup and texted him a picture saying that he had given to her.

The show was supposed to be a legal drama but the network asked the creator to change to a medical drama.

Tim Matheson, who plays Dr. Brick Breeland, is only five years younger than Maree Cheatham, who plays Grandma Bettie Breeland, Brick's mother.

Show creator Leila Gerstein was a big fan of Scott Porter in Friday Night Lights (2006) and wrote the role of George with him in mind.

There are several references to Taylor Swift in the second season. Taylor Swift is Jaime King (Lemon)'s friend and Taylor is Jaime's son's godmother.

The exterior of the doctor's office were changed after the first season.

The CW hired an aerial advertising service to fly a banner for this show around Bryant-Denny Stadium in Tuscaloosa during the September 24, 2011, Alabama-Arkansas football game.

When shows are shown overseas the titles are rarely exact translations of the English one, especially as it is often hard to translate a pun of an idiomatic expression, like this show's title. In other countries the titles (translated into English) include: "A Choice of the Heart" (Brazil); "The Southern Heart" (Serbia); "Heartland" (Finland); "Doctor in Alabama" (Portugal)"; Doctor of Hearts" (Hungary); "Zoe Hart from the Southern State" (Russia); "Zoe Hart" (french Canadian/Quebec).

Hassie Harrison, who plays "Lucy" (in episodes 3.12 Hart of Dixie: Should've Been a Cowboy (2014), 3.18 Hart of Dixie: Back in the Saddle Again (2014) and 4.7 Hart of Dixie: The Butterstick Tab (2015)), is in real life Wilson Bethels ("Wade Kinsella") girlfriend.

The Breeland sisters (Lemon and Magnolia) are both named after types of trees. Jaime King plays the part of Lemon while Claudia Lee plays Magnolia.

The house used as Wade Kinsella (Wilson Bethel)'s home would later be used in the Supergirl (2015) episode Supergirl: Truth, Justice and the American Way (2016), when the character of Alex Danvers is searching for the hideout of the Master Jailer, an alien on the loose.

Cress Williams (Lavon Hayes) and Scott Porter (George Tucker) also worked together on Friday Night Lights (2006) as Ornette & Jason respectively.

All of the episode titles from seasons 2-3 are also song titles.

While Rachel Bilson's character Zoe was pregnant in the story line, Bilson was also pregnant in her real life. She gave birth to her first child in October 2014.

Although Meredith Monroe plays character Lemon's mother, the actress is only ten years older than Jaime King. This came about because Monroe was first cast to play Lemon's mother only in flashbacks.

In Season 1, Episode 4, Hart of Dixie: In Havoc & In Heat (2011), Addy Picket (Eisa Davis) is the nurse helping Brick (Tim Matheson) & Zoe (Rachel Bilson) treat patients throughout the episode. Then in the next episode #5 - Faith & Infidelity Brick hires Addy to watch over Zoe in the office while Brick is hunting. Addy introduces herself to Zoe for the first time.

Season 1, Episode 4, Hart of Dixie: In Havoc & In Heat (2011), when Lemon (Jaime King) and George (Scott Porter) arrive at Fancies with George's parents there is an outside camera shot with Judson Lyon (Wes Brown) sitting at a table waiting for Zoe (Rachel Bilson) to arrive. It's the same camera shot from episode 7 - Hart of Dixie: The Crush & the Crossbow (2011).