The first letter of the names of each of the wooden animals that Rick Deckard carved in this movie: Rhino, Antelope, Cat, Horse, Elephant, Lion, spell "RACHEL".
To make Joi (Ana de Armas) appear more artificial, editor Joe Walker experimented by freezing her image for nine frames just before she responds to a question. That way it looked like her program paused for a split second, as if her processor was briefly occupied in coming up with an answer. However, it felt corny and it was decided that her artificiality was already convincingly communicated through her fast costume changes and transparency.
David Bowie was director Denis Villeneuve's first choice for the role of Niander Wallace, but he died six months before the start of shooting. Jared Leto was cast instead because of his "similar rock star vibe," since he fronts the rock band Thirty Seconds to Mars.
Production designer Dennis Gassner based the design of Niander Wallace's lair on one of the rooms in Kiyomizu-dera, the famous ancient temple in Kyoto, Japan. The floor type used for the lair is the uguisubari or the nightingale floor, where the noise created alerts a person to a possible intruder.
As seen in this movie, the baseline test that "K" must recite back ("A system of cells interlinked within / Cells interlinked within cells interlinked") was Ryan Gosling's idea. He employed an acting technique called "dropping in", which induced a trance-like and hypnotic effect on his performance.