In one episode, Emma runs away to the Tipton Hotel where Mr. Moseby (Phill Lewis) is working. After giving Jessie some advice, Mr. Moseby is on the phone with Cody Martin (from The Suite Life series) and says, "I'm telling you, Cody--this girl looks just like Bailey!" Before playing Jessie, Debby Ryan was Bailey on The Suite Life on Deck (2008).

While Luke is portrayed as older than Ravi (the former being born in August 1999 and the latter in March 2001), Cameron Boyce is actually four months younger than Karan Brar (May 1999 and January 1999 respectively).

On this show, Karan Brar (Ravi), uses a fake accent to sound Indian, like where his character is from. He really has an American accent, as he is from Redmond, Washington.

This series takes place in the same world as Austin & Ally (2011), hence the magazine "Leopard Beat" a parody of "Tiger Beat".

The pictures on the piano are real pictures of the actors and actresses as babies.

This show takes place in the universe as Good Luck Charlie (2010), Austin & Ally (2011), Shake It Up (2010), Liv and Maddie (2013), Best Friends Whenever (2015), Girl Meets World (2014), I Didn't Do It (2014), and That's So Raven (2003). Because Hannah Montana (2006) and Wizards of Waverly Place (2007) crossed over with The Suite Life of Zack and Cody (2005), and Mr. Moseby made a cameo on this show, and Raven goes to the Tipton hotel in season four of That's So Raven (2003), makes logical sense that those two shows are also in the same universe as this show.

Emma (Peyton List) is the only biological daughter of Morgan (Charles Esten) and Christina (Christina Moore). Luke (Cameron Boyce) was adopted from Detroit, Ravi (Karan Brar) was adopted from India, and Zuri (Skai Jackson) was adopted from Uganda.

The kids attend Walden Academy Public School. In reality, it exists in Willows, California, not New York City.

Originally had plans to be the longest running Disney show but plans were changed eventually

This show was so popular, that Disney rewarded it with a spin-off. However, in the spin-off, Cameron Boyce (Luke) doesn't star in it, due to him starring in Disney XD's Gamer's Guide to Pretty Much Everything (2015), and there is a rule that "if you want to star in a new show, you cannot continue working on your current show. There is an exception with filming a movie", so Cameron had to choose. He chose Gamer's Guide.

In the last episode of The Suite Life of Zack and Cody (2005), Mr. Moseby says that it's his last day, yet he appears at the Tipton hotel a couple of years after saying this.

Karan Brar and Peyton List appeared in Diary of a Wimpy Kid: Roderick Rules (2011) and Diary of a Wimpy Kid: Dog Days (2012).

Though it is well known that Mr. Mosby (Phill Lewis), a character from The Suite Life on Deck (2008) appears in "Karate Kid-tastrophe", Matthew Timmons (who portrayed Woody on The Suite Life on Deck (2008)), another ex-castmate of Debby Ryan made an appearance in "Caught Purple Handed".

Jessie is a natural brunette.

In some episodes, there are references about the movie Grown Ups 2 (2013), and are said by Luke. Luke (Cameron Boyce) plays a role in both of the Grown Ups movies. Also, Adam Sandler guest starred on the episode "Punch Dumped Love".

The series finale aired on October 16, 2015.

An on-going joke was "Tony knows a guy".

Originally, Zuri was supposed to be an American girl named Olivia from Chicago. But the producers were so impressed by Skai Jackson's audition, that they wrote the whole role over.

Frank, a.k.a. Mrs. Kipling, appeared in one of new episode (2/17/15) of A&E's Storage Wars (2010).

Jessie had an animated episode called "Halloween Night at the Museum" featuring Spider-Man from Ultimate Spider-Man: Web-Warriors.

Ravi (Karan Brar) names one of Mrs. Kipling's baby lizards "Gupta", and in the other television show in which he stars, Bunk'd (2015), he said that one of his middle names is Guptanium. He also appeared in Diary of a Wimpy Kid (2010), Diary of a Wimpy Kid: Roderick Rules (2011), Diary of a Wimpy Kid: Dog Days (2012) as Chirag Gupta.

Jessie wears her hair curly in almost every episode.

Zuri is from Uganda, Ravi is from India, and Luke is from Detroit.

Luke's best friend is his stuffed Koala bear Kenny the Koala.

Zuri's imaginary friend is Millie the Mermaid.

Kevin Chamberlin (Bertram) plays as a villager in A Series of Unfortunate Events (2017), where he sticks to a moody character, such as Bertram.

When Betty Ford appeared on the Mary Tyler Moore Show, this was only one of three times a first lady has appeared on a sitcom in the history of television. The next time would be Nancy Reagan on Diff'rent Strokes, and finally Michelle Obama appeared on the sitcom Jesse. Marla Maples, the former wife of future president Trump, would appear on Spin City in the 90s. The only time a president has appeared on a sitcom was when Donald Trump appeared on Suddenly Susan in the 90s;( although he was not yet president at this point.) Ironically he co-starred with comedienne and future Trump-hater Kathy Griffin. There has been no sitting president that has appeared on a scripted TV show in the history of television. Also in 1995, the potential future Presidential candidate Hillary Clinton was given the idea by her people to appear on the popular sitcom Home Improvement as a guest role. At the time, Hilary Clinton was the first lady and it was thought that appearing on Home Improvement would make her more likable. But this was also scuttled at the last minute.

Zuri, Luke, and Ravi are adopted.

In season one, episode twenty-five, "Gotcha Day", Morgan and Christina say that Ravi was born in 2001. However, Karan Brar was actually born in 1999.

In the episode where Ravi, Luke, and Bertram get stuck in the tea cup, the sign says Tipton Tea. Debby Ryan (Jessie) used to play Bailey in The Suite Life on Deck (2008) aboard the S.S. Tipton for high school. In a later episode, Emma runs away to the Tipton Hotel where The Suite Life of Zack and Cody (2005) took place, and Phill Lewis (Mr. Moseby) makes an appearance.