According to Neil Gaiman, co-author Terry Pratchett's last request to him before his death in 2015 was for Neil to write the screen adaptation. Previous attempts to bring the book to television failed due to not being able to find a writer able to adapt the book while keeping its spirit and humor.

The final scene Michael Sheen filmed was the Nazi scene in Good Omens: Hard Times (2019). He had to excuse himself to cry once he was done.

Terry Gilliam tried to adapt this as a movie several times over ten years before admitting defeat. He came closest in January of 2002 when he had Robin Williams on board to play Aziraphale, and Johnny Depp was signed up for the part of Crowley. He had raised fifty million dollars from investors and he just needed a Hollywood studio and a bit more money to start production. His confidence in the project was completely shattered when he found himself in a post 9/11 yet pre-Pirates of the Caribbean: The Curse of the Black Pearl (2003) Hollywood where every studio and producer he met told him the same thing: "nobody wants to see Johnny Depp movies".

Adam's earthly father, Mr. Young, has the license plate number "510RAT" which reads "TARDIS" backward. The Tardis is the time traveling police box featured throughout Doctor Who (2005), a show in which many of the "Good Omens" cast has also starred or appeared, most prominently David Tennant in the title role from 2005-2010. This is one of numerous "Doctor Who" Easter eggs that appear throughout the series.

Most music throughout the series is from Queen. This is a running joke in the source book, in which every cassette tape left in Crowley's car for a fortnight, magically turns into "The Best of Queen."

Terry Pratchett famously included several humorous footnotes in most of his novels. Neil Gaiman attempted to include as many of the Good Omens footnotes as possible in the show as Easter eggs. An example is the table tennis set which belongs to the Chattering Order of Saint Beryl.

The demon Crowley takes his name from the English occultist Aleister Crowley. The original Crowley was branded 'The most evil man alive' by the newspaper publisher Lord Beaverbrook. Crowley conducted rituals to try to produce the Antichrist who he named Moonchild. Jimmy Page, the guitarist of Led Zeppelin fame, was a great fan of Crowley and even bought his former home at Boleskine near Loch Ness.

Neil Gaiman revealed at a panel during New York Comic Con 2018 that the Bentley used in the show is a 1934 model. Neil admitted that no research was done on cars during the writing of the book, so when it came time to select a car for the show they found that the 1929 model mentioned in the book did not have the look that the authors had been going for.

Josie Lawrence plays the witch Agnes Nutter, a part Lawrence also played in the 2014 BBC Radio 4 adaptation of Good Omens.

Following one hundred nine consecutive days of filming, principal photography ended on March 10, 2018 in Cape Town, South Africa.

Crowley's watch is a Devon Tread 1 A.

Beelzebub is the Lord of the Flies in traditional theology, and is shown wearing a large fly as a headdress. In a humourous flourish, Dagon, usually depicted as a fish-demon, is here reimagined as the "Lord of the Files" in Hell's bureaucracy as a counterpoint to Beelzebub.

Madame Tracy lives in the same building as Shadwell, a witch hunter. Miranda Richardson, who plays Madame Tracy, has played a witch on at least two notable occasions: in Sleepy Hollow (1999), and Harry Potter and the Goblet of Fire (2005).

In a DVD extra, it's suggested that Jon Hamm's Archangel Gabriel is modeled as a celestial version of his Mad Men (2007) character Don Draper.

Three 'Doctor Who' actors, David Tennant (the 10th Doctor) and Michael Sheen (voice of House in Doctor Who: The Doctor's Wife (2011)), star as the leads. Also in this series are Dr. Who costars Derek Jacobi who played The Master and Michelle Gomez who played Missy. Benedict Cumberbatch, who appears as Satan, played Sherlock Holmes in the show Sherlock (2010). Mark Gatiss who acts in this series was also a writer for Doctor Who and co-creator of Sherlock, and appears in both. Regular Sontaran Dan Starkey also makes a cameo, as do several other Sherlock and Dr. Who costars.

Michael Sheen, who plays the angel and book dealer Aziraphale, has said: "I first read "Good Omens" as a teenager and it's been one of my favorite stories ever since.' Michael Sheen was born in 1969, "Good Omens" was first published in 1990 - Sheen wasn't a teenager anymore.

Jon Hamm and Michael Sheen each played a boyfriend of Liz Lemon in 30 Rock (2006).

In November 2001, when Terry Gilliam was still developing the film adaptation, the Chicago Sun-Times exclusively revealed that Joseph Fiennes and Christopher Lambert would be playing the two angels Crowley and Aziraphale. Soon afterwards, Neil Gaiman's website refuted the item.

"Good Omens" marks the seventh time David Tennant and Nina Sosanya have worked together. Their other titles include People Like Us: The Actor (2001), Casanova (2005), Doctor Who: Fear Her (2006), "Love's Labours Lost", 96 Ways to Say I Love You (2015), and You, Me and Him (2017).

In Episode 3, when Chadwell is asking Cowley for money in the cafe; Vincent Price's, "Witchfinder General" movie is playing on the TV in the upper corner.

Neil Gaiman: In Good Omens: Saturday Morning Funtime (2019) (part 4), sitting in the theater with Crowley, shortly before Hastur appears on the screen and threatens him.

In Good Omens: The Doomsday Option (2019), the book that the American Gate Officer is reading when the Four Horsemen arrive at the airfield is "American Gods", another Neil Gaiman fantasy epic.

Daniel Mays, who plays the unknowing father to the Antichrist, also appeared in Doctor Who: Night Terrors (2011) as an unwitting father to a powerful entity.

The square at the end of Good Omens: The Very Last Day of the Rest of Their Lives (2019), supposedly Berkeley Square, is in fact Tavistock Square.