Mike West, Ja Green, David Frederick White, and Lyssa Browne were the only voice actors from the original to reprise their roles for the remake, whereas the other characters had new voice actors.
Nintendo of America's Dan Owsen due to being listed in the credits was once thought to be the voice of ROB 64 in this game up until 2016 when Star Fox Zero (2016) released, when David Frederick White stepped in confirming otherwise, stating that he reprised all his characters from Star Fox 64 (1997) in addition to taking on Andross, though he was uncredited for unknown reasons.
Unlike the original N64 version, this remake has no option to change the spoken language to Lylat, which replaced the lines with Banjo-Kazooie styled speech.