Sarah Lyons (voice) (as Heather Marsden)
Elder Owyn Lyons (voice)
Scribe Reginald Rothchild (voice)
Paladin Jensen / Officer Davis / Brother Gerard / Scribe Bowditch / Paladin Tristan / Project Purity Scientist (voice)
Officer Lepelletier / Mother Curie III / Scribe Vallincourt (voice)
Officer Lorin / Rosa Meitner / Project Purity Scientist (voice)
Split Jack (voice)
Mr. Stiggs (voice)
Lag-Bolt (voice)
Scribe Bigsley / Sparky (voice)
Hoover / Enclave Doctor / Enclave Hellfire Trooper / Enclave Scientist / Enclave Officer (voice)
Brotherhood of Steel GNR Commander (voice)
Griffon / Mr. Wint / Mr. Kidd / Ghoul Guard (voice)
Operations Officer Edwards (voice)