The movie poster showing Ryan Reynolds carrying Samuel L. Jackson is a spoof of the poster for The Bodyguard (1992) where Kevin Costner is carrying Whitney Houston. Even the taglines are the same (albeit with pronoun changes).

Samuel L. Jackson spoke one hundred twenty-two cuss words throughout the movie.

Contrary to the way it is portrayed in the movie, Interpol is not a supranational law enforcement agency, and has no agents who are able to make arrests. Instead, it is an international organization that functions as a network of criminal law enforcement agencies from different countries. But, it doesn't matter in a fictional story.

Samuel L. Jackson performed the song "Nobody Gets Out Alive" at the end.

The song that Kincaid and the nuns are singing together in the van (much to Bryce's annoyance) is a 19th-century Italian traditional drinking song named "Bevilo Tutto", which encourages everyone to 'drink it all up'.

The men's wristwatch shown in detail at the beginning of the movie (while Michael Bryce (Ryan Reynolds) is getting dressed) is a Patek Philippe Sky Moon Tourbillon 5002P which has a 2017 street price of 1.2 million dollars.

The script from the film was among the top 2011 Black List of unproduced screenplays. While originally intended as a drama, the script underwent a frantic two-week re-write to be remade into a comedy several weeks prior to filming. On March 9, 2016, it was reported that Jeff Wadlow had exited the film and Patrick Hughes signed on to direct.

In September 2018, a sequel, titled, The Hitman's Wife's Bodyguard (2020) was announced starring Ryan Reynolds, Samuel L. Jackson, and Salma Hayek.

For a big stunt envolving two trams and some cars, the stunt team made a mistake and ruined one of the trams. The result was a major damage and a large bill. This accident can be seen in the gag reel.

The cuss word, "motherf*cker", is said a total of thirty-four times, twenty-two of which are said by Samuel L Jackson.

The prison where Sonia Kincaid (Salma Hayek), Darius Kincaid's (Samuel L. Jackson's) wife, is being held, is in reality the main office of the largest touristic boat company in Amsterdam. Bars on the windows and police activity around the building were added later in post-production.

The painting in Mr. Seifert's (Richard E. Grant's) office is a replica of "Judith Beheading Holofernes" (1599-1602) by Michelangelo Merisi da Caravaggio (1571-1610).

None of the scenes were shot in The Hague. Most noticably, The Hague does not have a subway system, nor are the trams white and green. All the arial shots with the The Hague skyline were added in post-production.

To shoot the scenes in Amsterdam, the streets around the famous Rijksmuseum were closed for several days. The result was the biggest traffic jam ever in the city and chaotic scenes on bike lanes.

Darius Kincaid (Samuel L. Jackson) and Michael Bryce (Ryan Reynolds) are taking a ferry from England to the Netherlands. In reality, their departure was filmed at the Passengers Terminal in Amsterdam, due to some logistic problems during shooting. In the background, you can see some typical Dutch canal houses.

During the scene where Micheal is taking out potential assassins of Darius whilst following him in Amsterdam an extra can be seen wearing Logan's jacket from X-Men Origins: Wolverine, a film that also stars Ryan Reynolds.

DIRECTOR CAMEO: (Patrick Hughes): Uncredited, the movie's director as an Interpol Agent.

The scenery in The Hague shows no resemblance with the real city. In fact, just some helicopter shots are showing the real city. In the last scene, the climax on the roof, government buildings situated in The Hague were added later in post-production.

The scenes in Coventry bear no resemblance to the real city. This was due to no filming taking place there with all scenes shot in or near Kensington.

Jeff Wadlow was going to direct the movie, but left to finish True Memoirs of an International Assassin (2016).

The song the nuns sing in the van with Kincaide is highly inappropriate for nuns.

The Helicopter that crashes near the end has a registration ID of PH-CEB, which is a registration for Royal Dutch Airlines (KLM) Convair CV-240. The aircraft was in service with Royal Dutch from 1948 until 1957. Source: KLM de geschiedenis van de KLM vanaf 1919 (the history of KLM from 1919).

The name of the group of nuns that Kincaid and Bryce travel with for a bit is painted on the side of their black & white hitop van, along with a picture of the sacred heart of Jesus. Their name - "Nuns of the Above".

Ryan Reynolds, Samuel L Jackson, and Richard E Grant have all appeared in movies based on Marvel Comics.

Amelia only calls Michael Bryce by his last name once.

Gary Oldman and Ryan Renynolds have appeared in movies based on comic books.

The bar (La Cucaracha) that Sonia Kincaid (Salma Hayek and Darius Kincaid (Samuel L. Jackson) dance in at the end is, translated into English, "The Cockroach", which is what Sonia calls Darius affectionately throughout the film.

WILHELM SCREAM: As Darius Kincaid (Samuel L. Jackson) is escaping by boat, the Scream can be heard when Michael Bryce (Ryan Reynolds), trying to keep up on a motorcycle, pushes a man off of a bicycle into the river.