The movie poster showing Ryan Reynolds carrying Samuel L. Jackson is a spoof of the poster for The Bodyguard (1992) where Kevin Costner is carrying Whitney Houston. Even the tag-lines are the same (albeit with pronoun changes).

Contrary to the way it is portrayed in the movie, Interpol is not a supranational law enforcement agency and has no agents who are able to make arrests. Instead, it is an international organization that functions as a network of criminal law enforcement agencies from different countries.

A video of its filming in Amsterdam turned up on social media networks showing a car chase. A Porsche Cayenne is shown crashing into a Smart and pushing it in the water. The video went viral and the story changed to it being a stolen car in a real chase.

Samuel L. Jackson spoke one hundred and twenty two expletives throughout the film.

Samuel L. Jackson performed the song Nobody Gets Out Alive at the end of the film.

The script from the film was among the top 2011 Black List of unproduced screenplays. While originally intended as a drama, the script underwent a "frantic" two-week rewrite to be remade into a comedy several weeks prior to filming. On March 9, 2016, it was reported that Wadlow had exited the film and Patrick Hughes signed on to direct the film.

During the trailer, the song "I Will Always Love You" by Whitney Houston from the movie The Bodyguard (1992) plays in the background.

the men's wristwatch shown in detail at the beginning of the movie (while Michael Bryce is getting dressed) is a Patek Philippe Sky Moon Tourbillon 5002P which has a 2017 street price of $1.2 million USD.

The police uniforms, logos and striping on the police cars are all incorrect. This is a discrepancy, but most likely not an error. Dutch police has in recent years become apprehensive to having its likeness being used by film and television productions. The filmmakers probably had to come up with alternative designs. Even Dutch productions have trouble getting approval.

The painting in Mr. Seifert's office is a replica of "Judith Beheading Holofernes" (1599-1602) by Michelangelo Merisi da Caravaggio (1571-1610).

Reunites Samuel L. Jackson and Gary Oldman for the third time. They previously appeared in True Romance (1993) and RoboCop (2014).

Michael Bryce's (Ryan Reynolds') line "This guy singlehandedly ruined the word 'motherfucker'" is not only in reference to Samuel L. Jackson's vulgar speech in this film, but is also a nod to many characters he has played before who used "motherfucker" excessively. A film most noteably known for the word "motherfucker" in Jackson's filmography, Pulp Fiction (1994).

This will be the second collaboration between Samuel L. Jackson and Ryan Reynolds after Turbo (2013).

Jeff Wadlow was going to direct the movie, but left to finish True Memoirs of an International Assassin (2016).

In Deadpool (2016), Wade Wilson/Deadpool (Ryan Reynolds) talks about Samuel L. Jackson and his role of Nick Fury. A little over a year later, the two actors appear in this film together.

This will be the second collaboration between Ryan Reynolds and Gary Oldman after Criminal (2016).

Reunites Salma Hayek and Joaquim de Almeida, who previously starred together in Desperado (1995).

Darius Kincaid (Samuel L. Jackson) sings the song Nobody Gets Out Alive to Michael Bryce (Ryan Reynolds). In Van Wilder (2002), one of Van Wilder's (Ryan Reynolds) key lines is "Don't take life too seriously; you'll never get out alive".

Gary Oldman and Tim Roth were originally thought of for Jules Winnfield and Vincent Vega in Pulp Fiction (1994) (They would've been called "The Two English Guys"), but the parts went to Samuel L. Jackson and John Travolta. Oldman and Jackson later appeared in this film.

Over one hundred crew personnel worked on both Europe set espionage themed movies Criminal (2016) and The Hitman's Bodyguard (2017). Stars Gary Oldman and Ryan Reynolds appeared in both films.

Contains 2 actors from the MCU (Marvel Cinematic Universe) Samuel L. Jackson as Nick Fury and Elodie Yung as Elektra (Daredevil and Defenders TV Series). The film also stars Ryan Reynolds who plays Wade Wilson/Deadpool in the Fox Universe (X-Men, Fantastic Four, etc...).

While mocking Ryan Reynolds on his history as a Triple A Bodyguard, Samuel L Jackson calls him a Triple X. This is a reference to the XXX films which Jackson appeared in.

Both Samuel L Jackson and Joaquim de Almeida were in Tom Clancy movies with Harrison Ford as Jack Ryan. Jackson was in Patriot Games and de Almeida was in Clear and Present Danger.

The bar that Sonia Kincaid (Salma Hayek and Darius Kincaid (Samuel L. Jackson) dance in at the end is, translated into English, the cockroach, which is what Sonia calls Darius affectionately throughout the film.

When Bryce (Ryan Reynolds) follows Kincaid (Samuel L. Jackson) in Amsterdam, there is a man dressed as Logan from X-men, referencing Reynolds' role as Deadpool.

As Darius Kincaid (Samuel L. Jackson) is escaping by boat, the "Wilhelm Scream" can be heard when Michael Bryce (Ryan Reynolds), trying to keep up on a motorcycle, pushes a man off a bicycle into the river.

In the scene where Kincaid is walking with the basket of tulips and Michael is killing the assassins behind him, a man is seen in the background with a walking stick and a distinct Wolverine beard and jacket on in homage to Reynolds Xmen co star Hugh Jackman.

Ryan Reynolds, Elodie Yung, Samuel L. Jackson, Richard E. Grant and Gary Oldman have all played comic book characters. Reynolds played Hal Jordan/Green Lantern in Green Lantern (2011), and Wade Wilson/Deadpool in Deadpool (2016). Yung played Elektra Natchios in Netflix's Daredevil (2015), Jackson played Nick Fury in the Marvel Cinematic Universe and Octopus in The Spirit. Grant played Dr. Zander Rice in Logan (2017), and Oldman played detective (later Commissioner) James Gordon in The Dark Knight Trilogy(2005~2012)

The "motherf*cker' explicative is said a total of 34 times, 22 of which are said by Samuel L Jackson.