The film was shot in sixteen days.
Jesse's (Justin Long's) King Charles Spaniel Zelda is Seth Rogen and Lauren Miller's dog in real-life.
The girls' phone number translates into 1-900-666-4666, a rare movie number that doesn't have 555 in it.
Lauren Miller and Justin Long also costarred in "Zack and Miri Make A Porno"
Seth Rogen: Jerry the airline pilot is Lauren Miller Rogen's husband.
Kevin Smith: New Jersey cab driver.