- In the aftermath of a massive earthquake in California, a rescue-chopper pilot makes a dangerous journey with his ex-wife across the state in order to rescue his daughter.
- In San Andreas, California is experiencing a statewide earthquake that goes on record as easily the biggest earthquake in history. Dwayne Johnson plays Ray Gaines, a helicopter rescue pilot for the Los Angeles Fire Department, who is trying to find his daughter, Blake (Alexandra Daddario), who is in San Francisco amid-st the chaos. Ray's estranged wife, Emma, is forced to turn to Ray for help, as he is her last resort. Together they journey to save their daughter.—ahmetkozan
- In Los Angeles, the Fire Department Air Rescue pilot Raymond "Ray" Gaines will drive his daughter Blake to San Francisco since she has joined the university. He is divorcing from his wife Emma that intends to move in together with her wealthy boyfriend Daniel Riddick. Meanwhile the researchers Dr. Lawrence Hayes and Dr. Kim Park from the Caltech travel to a dam to check their seismic studies and there is a strong earthquake collapsing the dam. Lawrence discovers that the San Andreas Fault is moving and will cause a huge earthquake in Los Angeles and San Francisco. Ray needs to travel to help the victims from the dam and Daniel offers to take Blake to San Francisco since he has a meeting in the city. Daniel brings Blake to his office and while waiting for him, she befriends the British architect Ben Taylor and his younger brother Ollie Taylor. When Ray is flying to the dam, there is an earthquake in Los Angeles and then the earthquake reaches San Francisco. What will happen next?—Claudio Carvalho, Rio de Janeiro, Brazil
- Chief Raymond Gaines, a former Afghanistan helicopter pilot and now a search-and-rescue pilot for the Los Angeles Fire Department, has to cope with a divorce and a painful family tragedy. When a sudden massive earthquake demolishes Hoover Dam, triggering a devastating string of quakes from L.A. to San Francisco by the entire length of the San Andreas fault, Ray will embark on a frenzied mission to rescue not only his estranged wife, Emma but also his trapped eighteen-year-old daughter, Blake. Inevitably, as scientists warn for yet another catastrophic seism, Ray needs to succeed in the most important rescue of his life, however, is there enough time?—Nick Riganas
- Helicopter pilot Raymond Gaines leads a military veterans rescue team in the LAFD, including Joby O'Leary. Gaines grudgingly misses out on a weekend with his daughter Blake, who announces being engaged to leading architect Daniel Riddick and moving in with him at San Francisco. After Caltech seismologist Dr. Lawrence Hayes's team spots worrying quake-predicting data, his colleague Dr. Kim Park follows up at the Hoover Dam, where he dies as at breaks down. As Hayes warns on TV, the persisting parameters indicate the whole San Andreas Fault is going to quake as badly, wrecking metropolises LA and San Francisco. Picking up his ex Emma, Gaines abandons his duty to search for Blake, even after her cellphone breaking down suggests her probably already being buried. Luckily for her, she was saved from the subterranean car parking of duly fleeing Riddicks's HQ by applying British architect Ben Taylor, who has a crush on her, encouraged as in all by his dashing kid brother Ollie, so the trio heads for higher ground despite the dim chances of rescue and the likelihood of further collapses, unaware there rescue is on its way.—KGF Vissers
- Raymond "Ray" Gaines (Dwayne Johnson) is a Los Angeles Fire Department Air Rescue pilot in the midst of a divorce from Emma (Carla Gugino) and planning a trip to San Francisco with his daughter Blake (Alexandra Daddario).
Meanwhile, Caltech seismologist Lawrence Hayes (Paul Giamatti) and his colleague Dr. Kim Park (Will Yun Lee) are at Hoover Dam doing research for a new earthquake predicting model when a nearby and heretofore unknown fault ruptures. This triggers a 7.1 magnitude earthquake that collapses the dam and kills Park.
When Ray is called into work because of this, Blake goes with her mother's new boyfriend Daniel Riddick (Ioan Gruffudd) to San Francisco, instead of Ray. Hayes discovers that the San Andreas Fault is shifting and will soon cause a major earthquake, thereby destroying cities along the fault line. Emma is having lunch with Daniel's sister Susan (Kylie Minogue) when the fault slips triggering a 9.1 magnitude earthquake, with Susan among the casualties during the event. Ray saves Emma from the collapsing building, and they barely escape the city aboard his helicopter.
In San Francisco, Daniel brings Blake to his office where she meets Ben (Hugo Johnstone-Burt), a engineering student from England seeking employment with his brother, Ollie (Art Parkinson). Daniel and Blake leave the premises but become trapped in their car in the parking garage after a string of earthquakes. Daniel flees but Blake is found by Ben and Ollie, who help her escape. They then find a working phone and Blake calls Ray and Emma, who fly to San Francisco to save her.
En route, Ray's helicopter fails, forcing him to make an emergency landing at a shopping mall in Bakersfield. Amid the chaos of looting, he steals a truck and he and Emma escape. They come across an older couple broken down on the side of the road where the San Andreas Fault has opened up, blocking the road and the couple, who happen to own an airplane agree to give it up in exchange for Ray's vehicle.
In San Francisco, Blake, Ben, and Ollie are trying to find a place to signal Ray, as the point they agreed to meet at, Coit Tower, is engulfed in flames. On approach, Ray and Emma are forced to parachute in the city when a 9.6 magnitude quake hits the city, becoming the largest earthquake in history. Much of the city is left in ruins and Blake, Ben and Ollie narrowly survive. Ray and Emma realizing they cannot make their way through the destroyed city, are able to commandeer a boat only to see that the water in the bay is beginning to recede, indicating that a tsunami is approaching.
As it approaches, Blake, Ben, and Ollie run into Daniel's building. The tsunami hits knocking over several buildings and leaving Daniel's building flooded. Daniel is killed on the Golden Gate Bridge when the tsunami washes in a cargo ship that severs the center span of the bridge. Emma and Ray make their way through the flooded downtown area and are finally able to locate Blake, Ben and Ollie as Daniel's building begins to sink beneath the water. Ray and Emma break a window and rescue Ben and Ollie however Blake apparently drowns. Ray is finally able to resuscitate her and the family is happily reunited.
They head to a relief camp where the reconciled Ray and Emma talk about their future as rescue vehicles descend on the radically altered landscape of the San Francisco Bay Area.
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