When addressing the cast and crew upon completion of principal photography, Pete Segal said that the cast and crew of Second Act was his "favourite family" of everyone he's worked with.
Principal photography was completed on December 15, 2017, with the film coming in on time and under budget.
When Maya and Ron are dancing at the Christmas party, they end up dancing the tango while having a disgruntled conversation. This nearly mimics the exact same scene from The Wedding Planner, in which Mary and Eddie also dance the tango.
The photo that Maya finds on her Facebook page of her with President Barack Obama and First Lady Michelle Obama is a real photo from the inaugural ball in Washington DC in January 2009 which Jennifer Lopez attended.
Food Bazaar Supermarket in Long Island City, New York, was used for location filming and remained open for three days while filming in October 2017.
The hard-discount store where Maya works was filmed in a Queens Food Bazaar, a 24-hour shop that was not closed for filming.
Second Act was shot entirely in New York. The filming started on October 20, 2017, and ended on December 15, 2017. Peter Segal wanted to make Manhattan a full-fledged character. Other places the team has invested in include the Bethesda Fountain in Central Park, the High Line, the streets of Soho, the South Street Seaport area, Madison Square Park, the Food Bazaar in Queens, the Rockerfeller Center, Villard Mansion at Lotte New York Palace Hotel, Dean & Deluca's, inside a metro train of the Metropolitan Transportation Authority, and the wharf of an air train.
Second Act was written by screenwriters Justin Zackham and Elaine Goldsmith-Thomas. The idea sprang up in their minds more than six years ago, in the early 2010s.