Of the six Bond movies that this video-game is based on, only the Skyfall (2012) mission is not included on the video-game disc itself. The reason for this is that the game is released one week before Skyfall (2012) launches in theaters. The video-game's 'Skyfall' DLC module is available as a free download after the release of the movie.

The video-game features an over-arching storyline inspired by six story-lines from six different James Bond movies, each individual one representing one of the six actors who have played James Bond in the official series: Goldfinger (1964) (Sean Connery), On Her Majesty's Secret Service (1969) (George Lazenby), Moonraker (1979) (Roger Moore), Licence to Kill (1989) (Timothy Dalton), Die Another Day (2002) (Pierce Brosnan) and Skyfall (2012) (Daniel Craig). However, the likeness of James Bond in all of the missions is that of Craig.

The likeness of the Ernst Stavro Blofeld character in the "On Her Majesty's Secret Service" mission is not based on one of the actors who played him in the official franchise but is actually an amalgamation of all three of the actors who officially played Blofeld seen in the Eon series: Donald Pleasence, Telly Savalas and Charles Gray. Savalas played Blofeld in the film On Her Majesty's Secret Service (1969).

The video-game is a first-person shooter genre video game, is playable in both single-player and multi-player modes and its media distribution is in two formats, disc and download. The video-game is released on four game platforms: PlayStation 3, Xbox 360, Wii U and Microsoft Windows.

Fourth James Bond video-game made and released by Activision. The first three were Quantum of Solace (2008), James Bond 007: Bloodstone (2010) and GoldenEye 007 (2010).

The game was developed in order to celebrate the Fiftieth Golden Anniversary of the official James Bond film series as well as tying-in with the release of the James Bond movie Skyfall (2012).

The likeness of Bond Girl Jinx in this video-game is not based on Halle Berry who played her in Die Another Day (2002) but instead is based on the likeness of Gabriela Montaraz. Similarly, the likeness of the Bond Girl character of Holly Goodhead is not based on Lois Chiles who portrayed her in Moonraker (1979) but is instead based on the likeness of Jane Perry.

The video-game is built on the same engine as developer Eurocom's previous Bond video-game GoldenEye 007 (2010).

The 24th James Bond video-game though its the 23rd if one doesn't count the spin-off Young Bond (1992). As such then, both this game and its associated movie tie-in, Skyfall (2012), represent an equal same number of titles that have been made within their media forms when both released in 2012.

The video-game is notable for featuring a number of the original actors from the official James Bond series, both current and former, voicing their respective characters. These include Naomie Harris as Eve; Michael Lonsdale as Drax; Richard Kiel as Jaws; Carey Lowell as Pam Bouvier; Toby Stephens as Gustav Graves; Judi Dench as M and Rory Kinnear as Tanner.

French actor Michael Lonsdale reprized his role as Drax in the "Moonraker" mission module of the 2012 James Bond video-game 007 Legends (2012) a massive thirty-three years after he played the role in the original 1979 Bond movie Moonraker (1979).

The surname of the Ernst Stavro Blofeld character, played in Spectre (2015) by Christoph Waltz, was named after Thomas Blofeld, with whom James Bond creator Ian Fleming went to school with at Eton College. Also known as Tom Blofeld, he was a Norfolk farmer, a fellow member of Boodle's, and the Chairman of the Country Gentleman's Asssociation. His son is cricket commentator Henry Blofeld. Ernst Blofeld's date of birth in the literary James Bond stories is the same date as Fleming's birthday which is 28th May 1908.

According to the book 'James Bond: A Celebration' (1987) by Peter Haining, who passed away in 2007, "Jules Verne's Captain Nemo was the inspiration for [Ian] Fleming's Ernst Stavro Blofeld" (who is portrayed in Spectre (2015) by Christoph Waltz). The book states that the character " . . . has his origins in Caprtain Nemo, the hate-fuelled rebel of Jules Verne's classic novel Twenty Thousand Leagues Under The Sea [1870]". Blofeld was originally intended to be the villain in The Spy Who Loved Me (1977).

The final mention of Ernst Stavro Blofeld (played in Spectre (2015) by Christoph Waltz) in a James Bond creator Ian Fleming story, was at the start of Fleming's "The Man with the Golden Gun" (1965) book, his final full Bond novel.

Four James Bond movies have featured leading Bond Girls with a doctor qualification. Spectre (2015)_ is the first James Bond movie in around sixteen years where a leading Bond Girl has had the profession of being a doctor. In Spectre (2015), Léa Seydoux's character is Dr. Madeleine Swann, a Doctor of Psychology, and is the fourth major Bond Girl in the official series to be a doctor. The last time in the film franchise that a Bond Girl was a doctor there were two, Dr Christmas Jones (Denise Richards - a doctor of nuclear physics) and Dr Molly Warmflash (Serena Scott Thomas - a doctor who is a physician to MI6 agents), both appearing in The World Is Not Enough (1999). Prior to this, the first leading Bond Girl who was a doctor was Dr Holly Goodhead (Lois Chiles) (a CIA agent and an astronaut space scientist doctor of astrophysics) in Moonraker (1979). In the James Bond video games, James Bond in Agent Under Fire (2001) features Dr. Natalya Damescu (Beatie Edney - voice); James Bond 007: Everything or Nothing (2003) features Dr. Katya Nadanova (Heidi Klum); and 007 Legends (2012) also features the above-mentioned Dr. Holly Goodhead (Jane Perry), whilst The World Is Not Enough (2000) also features Dr. Christmas Jones (Sumalee Montano) as well as archive footage of Denise Richards from the movie version also in the video-game.

Ernst Stavro Blofeld, portrayed in Spectre (2015) by Christoph Waltz, is one of three recurring villains in the official James Bond film franchise series. The other two are henchmen Jaws (Richard Kiel), from Moonraker (1979) and The Spy Who Loved Me (1977), and Mr. White (Jesper Christiansen), from Spectre (2015), Casino Royale (2006), and Quantum of Solace (2008). Of these three recurring villains, two, Mr. White and Ernst Stavro Blofeld, both appear in one of the same films, which is Spectre (2015). Of the three villains, only two, Jaws and Mr. White, are the only ones who have always been portrayed by the same actor.

The character of Ernst Stavro Blofeld has appeared in the following major and/or official James Bond movies and video-games (in order): From Russia with Love (1963), Thunderball (1965), You Only Live Twice (1967), On Her Majesty's Secret Service (1969), Diamonds Are Forever (1971), informally in the official film For Your Eyes Only (1981), in the unofficial film Never Say Never Again (1983), GoldenEye 007 (2010), GoldenEye: Rogue Agent (2004), 007 Legends (2012), and Spectre (2015) .

Spectre (2015) is the second of two major appearances of the Ernst Stavro Blofeld character in the official James Bond film franchise where Blofeld is seen with hair, as he had been in Diamonds Are Forever (1971) where he was played by Charles Gray. In both You Only Live Twice (1967) and On Her Majesty's Secret Service (1969), Blofeld was bald, being portrayed by Donald Pleasence and Telly Savalas respectively. In minor roles and appearances, Blofeld was bald in the unofficial appearance in For Your Eyes Only (1981), but had hair in Thunderball (1965) , From Russia with Love (1963), and the unofficial film, Never Say Never Again (1983).

The Ernst Stavro Blofeld villain character returns to the official film franchise in Spectre (2015) but since he last appeared in the official series films Diamonds Are Forever (1971) and informally in For Your Eyes Only (1981) and the unofficial entry Never Say Never Again (1983), Blofeld has actually appeared in three James Bond video-games. The Wikipedia website states: "Blofeld appears in the 2004 video game GoldenEye: Rogue Agent [GoldenEye: Rogue Agent (2004)], this time with the likeness of Donald Pleasence [from You Only Live Twice (1967)], voiced by Gideon Emery. Blofeld is a playable multiplayer character in the 2010 video game GoldenEye 007 [GoldenEye 007 (2010)] for the Wii, with the likeness of Charles Gray [from Diamonds Are Forever (1971)]. Blofeld is one of the main characters in the 2012 video game 007 Legends [007 Legends (2012)], featured in the mission based on On Her Majesty's Secret Service [See On Her Majesty's Secret Service (1969)], in which the character was an amalgamation of the three actors [who had] appeared in the official film series [they being Telly Savalas, Charles Gray, & Donald Pleasence]. Throughout the game, he is voiced by Glenn Wrage."