Daily Lives of High School Boys (man is that an unwieldy title) is one of the more surprising anime series to come along recently. What originally looked like a male version of K-ON and its ilk turns out to be a quite funny parody of that kind of series. The show nicely translates the anxieties of teenage life into hyperbolic comic characters, making especially good hay out of the way girls and boys think of each other as alien species that you might one day like to date.
I believe this is from the same creator as School Rumble, and like that show this is a bit hit or miss but a still generally pleasant riff on high school anime. It's not a brilliant must-see series, but it probably won't let you down either.