Continuing his outspoken advocacy for the use of film stock over digital formats, Cinematographer Wally Pfister not only chose to shoot the film in the anamorphic format on 35mm film instead of on a digital camera, but also finished the film photochemically, refusing to use a digital intermediate.

Christopher Nolan had eyed the project for some time while finishing up The Dark Knight Rises (2012) before taking on Interstellar (2014), believing Transcendence was "perfect" for Wally Pfister's debut as a director.

When Evelyn checks into the hotel that Will reserved for her after transcending, she tells the check-in attendant that she has a reservation under the name "Turing". Alan Turing (1912-1954) was a British mathematician and computer scientist who was the inventor of the Turing Test, a process where a person communicates with a live person and a computer, without seeing, and has to figure out which one is the live person. He also developed the "Turing machine", a theoretical computing model that is the conceptual basis of digital processing. He is widely considered to be one of the fathers of computing in general, and artificial intelligence in particular.

The screenplay for this film was featured in the 2012 Blacklist; a list of the "most liked" unmade scripts of the year.

Morgan Freeman, Rebecca Hall, Cillian Murphy, Josh Stewart, Lukas Haas, and Casting Director John Papsidera all previously worked with Wally Pfister, on the films he shot for Christopher Nolan.

Wally Pfister's directorial debut.

The film takes place in 2021.

This is not the first time that Paul Bettany is connected with super computers and high technology. Bettany provided the voice of Jarvis, Tony Stark's computer, in the Marvel Cinematic Universe.

James McAvoy, Tobey Maguire, Christian Bale, and Jude Law were considered for one of the lead roles.

Ewan McGregor and Tom Hardy turned down the role of Max, due to scheduling conflicts.

The car arranged by Evelyn to transport Joseph and Agent Buchanan after their visit to Brightwood Data Center is an Electric Zero-Emissions Nissan LEAF.

Noomi Rapace was an early choice for the role of Evelyn. The final choices were Emily Blunt, Rooney Mara (sister of Kate Mara who plays Bree) and Rebecca Hall. Both Noomi Rapace and Rooney Mara have played Lisbeth Salander in the Stieg Larsson movies.

James Thomas has a captcha in his left wrist with the word "UNPLUG".

Alison Brie auditioned for the role of Bree, before Kate Mara was cast.

Noomi Rapace was considered for the lead role, while Kate Winslet turned it down, due to scheduling conflicts.

At the end when the camera pans through the quantum computer array, on the left is Japanese katakana written on the left side. This means "computing".

When Rebecca Hall arrives in Brightwood, there is a sign that says "everything must go". She previously starred in the movie Everything Must Go (2010).

Contains a lot of comic book movie actors and actresses. Johnny Depp was in From Hell (2001), Morgan Freeman, Josh Stewart and Cillian Murphy were in the Dark Knight trilogy, Paul Bettany and Rebecca Hall were in the Marvel Cinematic Universe, and Bettany was also in Priest (2011), and Kate Mara was in Zoom (2006) (indirectly related to comic books) and Fantastic Four (2015), and also had a small role in Iron Man 2 (2010), as a role of U. S. Marshal, at the beginning of the film.

Received a "C+" CinemaScore.

Rebecca Hall, Paul Bettany, and Kate Mara have all appeared in the Marvel Cinematic Universe. In Iron Man 2 (2010), Kate Mara had a small role as the U.S. Marshal, and Paul Bettany provided the voice for J.A.R.V.I.S.. In Iron Man 3 (2013), Rebecca Hall had the role of Maya Hansen, and Paul Bettany provided the voice for J.A.R.V.I.S. again.

When Evelyn enters the Internet cafe the individual on her right is playing World Of Warcraft.

Rebecca Hall, Paul Bettany and Kate Mara have all appeared in the Iron Man trilogy, whilst Morgan Freeman and Cilian Murphy have both appeared in all three instalments of the Dark Knight trilogy.

Elon Musk: brief medium close-up, in the lecture hall scene.

The use of polonium by RIFT to poison Will is a method first used in the murder of former KGB officer Alexander Litvinenko in London in 2006.

The copper-wire mesh that Will constructs around his yard at the beginning of the film, and Max's team later uses to capture Martin, is a Faraday Cage, a concept which is normally employed on a smaller scale to protect sensitive electronics from RF interference.