The Mindy Project was cancelled by FOX on May 6, 2015. It was picked up by Hulu a week later.

Mindy Kaling named her character Mindy Lahiri after acclaimed Indian-American author Jhumpa Lahiri.

Chris Messina (Danny Castellano) played a small role in You've Got Mail (1998), a film that is frequently mentioned by Mindy (Mindy Kaling) and Danny throughout the show.

Chris Messina missed the shooting of four consecutive episodes in season four, because he was busy filming Live by Night (2016). Nevertheless, he did guest voices in each episode.

Various actors and actresses in the show have appeared in The Office (2005), including Mindy Kaling, B.J. Novak, Ellie Kemper, Anna Camp, Kelen Coleman, Zoe Jarman, Ed Helms, Timothy Olyphant, Beth Grant, and Paul Lieberstein.

In the show, Mindy mentions numerous times how she's from Boston, Massachusetts. In real-life, Mindy is from Cambridge, Massachusetts. Also, Mindy plays a gynecologist, while in real-life, her late mother was a gynecologist.

The role of Dr. Jean Fishman was written specifically for Niecy Nash.

The nightime establishing shots of the fictional "St. Brendan's Medical Center", are actually shots of Hahnemann University Hospital in Philadelphia, Pennsylvania, even though the show is set in New York City. This is more obvious in some shots, which actually include Philadelphia City Hall in the background, topped with the statue of William Penn.

Dan Hedaya and Rhea Perlman played a former couple on Cheers (1982).

In the show, Danny Castellano's parents are played by Rhea Perlman and Dan Hedaya, who are no longer together, with his mother having nothing good to say about his father, who left her when the kids were young. Perlman and Hedaya also played ex's Carla and Nic Tortelli on Cheers (1982), who are the parents of four kids, where Perlman's character Carla again had nothing good to say about Hedaya's character Nic, who also left her when their kids were young.

Beth Grant (Beverly) and Garret Dillahunt (Jody Kimball-Kinney) appeared in No Country for Old Men (2007).

Chris Messina (Dr. Danny Castellano) and Jenny O'Hara (Dot), Danny's mother's best friend, appeared in Devil (2010).

Many of the shows guest stars, including B.J. Novak, Ellie Kemper, Ed Helms, and Paul Lieberstein appeared on The Office (2005).

Mindy Kaling and Beth Grant appeared in The Office (2005) season four, episode nine, "Local Ad".

Mindy Kaling and Reese Witherspoon appeared in A Wrinkle in Time (2018).

Two stars of the 90's sitcom Wings made appearances on The Mindy Project: Tim Daly and Steven Weber.

In season three, episode sixteen, "Lahiri Family Values", Mindy (Mindy Kaling) and Rob Gurglar (Tate Ellington) go to the bank in San Francisco to apply for a small business loan. The street shots around the bank were filmed in Toronto, Ontario, not San Francisco. Specifically, they were filmed at the corner of Yonge and Queen streets, which are easily identified by the distinctive street signs.