The film marks Goldie Hawn's return to the big screen, fifteen years after she starred in The Banger Sisters (2002).
The film's studio originally didn't want Goldie Hawn for the film; however, co-star/producer Amy Schumer insisted and even threatened to leave the project if Hawn wasn't cast.
During breaks in filming, Amy Schumer and Wanda Sykes performed several "pop-up" shows in Honolulu, with all proceeds going to charity. The shows were announced in the morning and would sell out in a matter of hours.
Amy Schumer was hospitalized with Chronic Bronchitis during filming which shut down production for a week.
All filming was done in Hawaii although much of the film takes place in Ecuador and Colombia.
When Emily is shouting for the chicken truck to slow down, she says "sientate", which means "sit down".
Rapper and 'F*ck, That's Delicious' star Action Bronson read for the role of the boyfriend.