Takes place in the same universe as Ultimate Spider-Man (2012), Avengers Assemble (2013) and Guardians of the Galaxy (2015), designated Earth-12041.

Although it's never mentioned in the series, in the comics, Skaar is actually the biological son of Hulk. It remains unclear why this story element was never introduced in this show.

Several characters make reference to having seen Marvel Cinematic Universe films such as The Avengers (2012) and Guardians of the Galaxy (2014), making the MCU a fictional part of this version of the Marvel Universe (Earth-12041).

This show features two cast members that had appeared in Buffy the Vampire Slayer (1997), Seth Green and Eliza Dushku.