Comedian Nick Helm (Andy) explained that the show was inspired by Wes Anderson's comedy film The Royal Tenenbaums (2001).

Uncle is filmed on-location in Croydon. Exterior scenes have been filmed at George Street, Thornton Heath and Surrey Street Market. Interior locations include the Hustler Club and a house in Purley.

The original pilot was broadcast on Channel 4, although the following two series were broadcast on rival channel BBC Three.

The official soundtrack album, featuring original songs by Nick Helm, is available to buy.

Following the decision to convert BBC Three into a digital-only channel, there was speculation that any potential third series of Uncle might be moved to BBC Two. However, in December 2015 the third series was announced by the BBC, with a strong suggestion that it would remain on BBC Three as an online broadcast, followed by repeats on BBC One.

The programme premiered in Australia on 12 January 2015 on SBS One, and also features on Australian online streaming service, Stan.

Broadcast of the series was aired in Saudi Arabia and the Middle East in the summer of 2015 by BBC Entertainment on Orbit Showtime Network (OSN).

As of late 2017, the complete series is available for streaming on Netflix Canada.

Esther Smith (Melodie) & Daniel Lawrence Taylor (Bruce) also worked together on Cockroaches (2015) as Suze & Tom respectively.

Esther Smith (Melodie) & Daisy Haggard (Sam) also worked together on Ballot Monkeys (2015) as Charlotte Guthrie & Christine Proctor respectively.

The pilot episode was first broadcast on Channel 4 in December 2012, before the show was commissioned by BBC Three. The first episode from the series, a remake of the pilot, aired on 13 January 2014.

Series 3 was announced as the final series by Nick Helm on Twitter. It started on 1 January 2017 on BBC Three on the BBC iPlayer and then the television main release on BBC One on 6 January 2017.

The show was renewed for a second series, and it began on BBC Three on 10 February 2015.

In December 2015 it was announced that the programme would return for a third series.

The complete first series of Uncle was released onto DVD on 16 March 2015.