Max (Jason Bateman) and Annie (Rachel McAdams) make a joke about child actors not amounting to much. Bateman was a child actor famous for his role in Silver Spoons as well as in Valerie (1986).
A tilt-shift lens is used to give several wide aerial shots the miniaturized look of the Game of Life board game.
Prior to filming, the cast members had their own "game night" so they could get to know one another and prepare for the film. They played Clue and Joking Hazard.
Jason Bateman was originally set to direct the film, but John Francis Daley and Jonathan Goldstein would only work on a rewrite of the script if they could also direct.
After Annie (Rachel McAdams) accidentally shoots Max (Jason Bateman), she attempts to perform minor surgery on him to remove the bullet using a pair of tweezers, much in the same way players remove parts from the body in the game Operation.
In addition to referencing Quentin Tarantino's films Pulp Fiction (1994) and Django Unchained (2012), the movie includes a scene filmed in a single take, a technique often used by Tarantino.
In the underground rich person fight club scene, Donald Anderton (Danny Huston) introduces a new fighter, Logan. Danny Huston also played Stryker in Xmen Origins: Wolverine, where he was responsible for giving Wolverine (Logan) his adamantium skeleton.
Ryan (Billy Magnussen) keeps referencing an underground fight club. During a guessing game, Max (Jason Bateman) has to get Annie (Rachel McAdams) and his friends to guess the actor Ed Norton. Edward Norton was one of the main stars of Fight Club (1999).
The real name of the actor who plays 'Not Denzel' is Malcolm X. Hughes. Denzel Washington played the lead role in Malcolm X (1992).
In keeping with the theme of games referenced in the film, there is a subtle reference to a classic 1970s board game. When the group first enter Donald Anderton's (Danny Huston) lavish home, the painting "Old Man with a Gold Chain" by Rembrandt can be seen hanging on the wall. This is one of the paintings from the Art Institute of Chicago which is featured in the board game Masterpiece.
Director John Francis Daley played Carter in the film. In Horrible Bosses (2011) he played a character also named Carter.
This was the second film Jason Bateman and Rachel McAdams starred in together. The first was State of Play (2009).
Jesse Plemons and Billy Magnussen both appeared in the Black Mirror (2011) episode Black Mirror: USS Callister (2017).
The character of Gary Kingsbury, played by Jesse Plemons, was named after John Francis Daley's wife, Corinne Kingsbury.
The opening title sequence shows game pieces from many classic board games including Battleship. Battleship is later referenced as a game Max (Jason Bateman) and Brooks (Kyle Chandler) played as kids. Jesse Plemons who plays Gary had a role in the movie Battleship (2012).
The film contains references to Iron Man (2008) and The Incredible Hulk (2008) from the Marvel Cinematic Universe. Rachel McAdams had a role in Doctor Strange (2016), also from the MCU.
Kyle Chandler and Jesse Plemons both starred on the TV show Friday Night Lights (2006).
One of the filming locations was RiRa Irish Pub, 1010 Peachtree Street. NE, Atlanta, GA on April 4, 2017.
There is a scene where all the game players are face down on the street and Kyle Chandler (Brooks) confesses to Jason Bateman (Max) that he used to cheat at the game "Battleship". Jesse Plemons played the character Jimmy Ord in the 2012 film version of Battleship (2012) based on the game.
The film was promoted on February 12, 2018 in Atlanta, Georgia by Micaela Dee and her fellow "Murder Mystery Dinner Theater" players.
In memory of stuntman John Bernecker, who died in July 2017, whilst filming The Walking Dead (2010) in Atlanta, Georgia, where the filming of [Game Night] took place. John Bernecker also performed stunts on the film Battleship (2012) which starred Jesse Plemons (Gary).
While playing Jenga at Gary's house, he makes a comment about not knowing "chemistry". Jesse Plemons, who plays Gary, also played Todd on Breaking Bad (2008). Todd relied on his knowledge of chemistry to make crystal meth.
Both Jesse Plemons and Kyle Chandler have starred in Grey's Anatomy (2005). Plemons played Jake Burton in season two, a patient with advanced craniodiaphyseal dysplasia. Chandler starred as Dylan Young, from the bomb squad in season two.
This was the second film Rachel McAdams and Michael Cyril Creighton appeared in together. The first was Spotlight (2015).
The Character Gary is likely named after the creator of the Role-playing game Dungeons and Dragons "Gary Gygax".