The film was based on the true events of the lives of former high school classmates (Bill Akers, Patrick Schultheis, Sean Raftis and Mike Konesky). As teenagers during the 1980s, they would entertain themselves by playing the schoolyard game during breaks at Gonzaga Preparatory School in Spokane, Washington.

Jeremy Renner fractured his right elbow and left wrist while filming a stunt for the movie.

The booby traps and sound effects used for the chase sequence in the woods are direct callbacks to Predator (1987).

Will Ferrell and Jack Black were originally part of the cast.

The movie was filmed in metro Atlanta.

Despite playing their classmate, Hannibal Buress is twelve to five years younger than his co-stars.

The basis of the film originates on a game being played for thirty years. The playground game of "tag" was big during the 1980s. Several movies during the 1980s capitalized on the craze, including Tag: The Assassination Game (1982) and Gotcha! (1985).

The film reunited Ed Helms and Rashida Jones, who served character roles in The Office (2005-2012).

Jeremy Renner and Jon Hamm both also starred in The Town (2010).

Jon Hamm and Isla Fisher were both also in Keeping Up with the Joneses (2016).

This film marked the second collaboration between Jake Johnson and Annabelle Wallis, following The Mummy (2017).

Jeremy Renner, Jake Johnson and Annabelle Wallis each starred opposite Tom Cruise in blockbuster films: Renner in Mission: Impossible - Ghost Protocol (2011) and Mission: Impossible - Rogue Nation (2015), and Johnson and Wallis in The Mummy (2017).

Jeremy Renner and Leslie Bibb both starred in the Marvel Cinematic Universe, with Renner as Clint Barton/Hawkeye in various films and Bibb as a reporter in Iron Man (2008) and Iron Man 2 (2010).

Ed Helms and Isla Fisher were both in Confessions of a Shopaholic (2009), although Helms' appearance in a self-help video was uncredited.

There are a number of connections between the cast and the Marvel Comics superhero Spider-Man. Jake Johnson plays Peter Parker in Spider-Man: Into the Spider-Verse (2018). Hannibal Buress plays Peter's coach in Spider-Man: Homecoming (2017). Jeremy Renner plays fellow superhero Hawkeye alongside Spider-Man in Captain America: Civil War (2016) and Untitled Avengers Movie (2019). Leslie Bibb appeared in Iron Man 2 (2010) with a young boy who was retroactively revealed to be Peter.

Second film starring Jake Johnson to be inspired by an item printed in a newspaper. His earlier film, 'Safety Not Guaranteed,' was inspired by a cryptic classified ad seeking someone to travel back in time.

This is the fourth movie that Ed Helms stars in that contains a song from Danzig, the other three being The Hangover trilogy. Just like in The Hangover part 3 (2013), we can here the song "Mother" in Tag.