Actors Erin Krakow and Daniel Lissing are both great singers and have sung together before. They have mentioned doing an album together.

On March 21, 2018, Hallmark Channel renewed the series for a sixth season to air in 2019.

Wendell Backus Is Coal Valley's town drunk. Bacchus is the name of the Roman god of wine and both names are pronounced the same.

Hamilton is the Canadian city frequently used in the show. Hope Valley is somewhere in the Pacific Northwest. A train ride from Vancouver to Hamilton would take about three days, according to today's trains and schedules, thus demonstrating that moving between Hope Valley and Hamilton would likely take even longer during the era in which the show takes place.

In March 2019, Lori Loughlin (Abigail Stanton) was indicted for bribing admissions officials so her children could be admitted to the University of Southern California. Hallmark announced on March 14, 2019 it was no longer working with Loughlin and had stopped development of any productions involving her. This caused a delay for When Calls the Heart: Heart of a Mountie (2019), which had been slated to air on 3/17/19 as Hallmark assessed what to do with the role. Loughlin, a U.S. resident, was specifically allowed by the Judge to keep her passport to travel to Canada to continue working with Hallmark on this show, but Hallmark terminated her. The agreement with the Judge expires in December after which Loughlin will have to surrender her passport. However, there is no public word on whether that has been modified since Hallmark took action. In April 2019, the federal government added money laundering charges after Loughlin and her husband did not plead guilty to the original charge after others charged in the case took did so. In order to edit out appearances of Loughlin's character Abigail, Hallmark did considerable editing for the remainder of Season 6, which ended up reducing the show count by one. It has not been determined if the character will be recast or written out.

The University Women's Club of Vancouver at Hycroft was used for the Thatcher home in Season 2.

The fans of this show are called Hearties. With over 60,000 members (and growing) on Facebook, the Hearties are valiant in their efforts to support the continued growth of this series.

Starting in season 2, most of the episodes of the show have the word "Heart" in the title including all of season 4.

Chelah Horsdal, Gracyn Shinyei, and Genea Charpentier all appear in the Amazon series, The Man in the High Castle. Gracyn and Genea are cast as Chelah's daughters.

The actors that portray the characters of Bill Avery and Nora were married in real life. Jack and Kristina Wagner played a married couple on General Hospital also.