I heard a lot about this before I watched it. And I seriously don't get all the fuss. Anyway I suffered through the whole movie, and for me it was horrible by all means.
If you want to see some nice animation, don't ever watch this movie. Technically it mixes animation styles: stop-motion and traditional frame-by-frame, but it fails so badly. And it's not that I don't like weird characters, but these are just too simple and unpretending. The animation is low frame, not flawless at all, and that makes the scenes even harder to embrace. The stop-motion scenes look awful, for example a house looks like a simple paperboard box, that a five year old would make as a mock-up.
About the story: there's not much to be told. Long story short: the main character has mental illness, and all her female family members too. Their life s*ck. Some of them commits suicide, but not her. The End.
In my humble opinion the movie is really depressing to watch, and there's absolutely nothing to enjoy about it. It's not interesting, or fun, or clever, it's just sad and ugly, and very dull. After this movie I felt nothing but a deep urge to kill myself, so I don't have to watch this anymore.
And her voice, which narrates everything, is so irritating, that I can't even describe it.
I didn't find anything in this movie that worths mentioning. OK, maybe the moral of the story. But the idea, that someone with mental illness can live together with normal people, is not enough, at least not for me, to keep me interested and/or entertained for a movie this long, or to make up for the wasted time, and for the insulting quality of animation.
Still I think the director/writer really tells the story of her life, which is nice, and she deserves all my respect for that. But if you go crazy in animation, do it with style! Please.