Viola Davis became the first African-American woman to receive an Emmy Award for Outstanding Lead Actress in a Drama Series because of her work on this show. She won in that category in 2015.

The iconic scene where Annalise Keating is wiping off her make up and removing her wig was Viola Davis's idea.

The title of every episode is part of the dialogue from the respective episode.

The series was inspired by the television series Damages (2007) and the movie Legally Blonde (2001) and incorporated some elements of those two mediums for this show.

Annalise's classroom in the pilot is an auditorium at Ursinus College in Pennsylvania. After filming the pilot, it was recreated as a set.

Karla Souza initially auditioned for the role of Michaela Pratt, then Rebecca Sutter before being asked by the show's creator Peter Nowalk to audition for the role of Laurel Castillo.

While on Ellen: The Ellen DeGeneres Show (2003), Viola Davis praised the makeup artists who apply the body makeup for her sex scenes. Davis said that when asked where she wanted makeup applied, She responded, "everywhere."

Shonda Rhimes considered the idea of doing a 15-episode season because keeping the tone of the show over more episodes would affect the show's whole picture negatively.

Viola Davis is an alumna of Juilliard.

Most of Rebecca Sutter's piercings are fake.

Viola Davis and Cicely Tyson both appeared in The Help (2011).

Matt McGorry and Alysia Reiner previously worked together on Orange Is the New Black (2013).

On 3rd January 2018, it was confirmed that How to Get Away With Murder would be doing a crossover episode with another of Shonda Rhimes' shows Scandal.

Charlie Weber (Frank Delfino) and Liza Weil (Bonnie Winterbottom) dated in real life as Charlie said "We were great friends and we found ourselves in a position to be more than that"

Viola Davis played a defense lawyer in Law & Order: Special Victims Unit (1999).

Viola Davis is shown defending an alleged killer in Philadelphia's City Hall in How to Get Away with Murder: Pilot (2014). Davis was previously seen working in there when she portrayed the Philadelphia mayor in Law Abiding Citizen (2009).

The name Mr. Darcy derives from Pride and Prejudice's Mr. Darcy

Liza Weil and Amy Okuda have appeared in Grey's Anatomy, another show created by Shonda Rimes.

Liza Weil (Bonnie Winterbottom) and Wilson Bethel (Charles Mahoney) have both starred in TV shows filmed in the same location. Liza appeared in Gilmore Girls (2000) playing Paris Gellar, while Wilson appeared in Hart of Dixie (2011) playing Wade Kinsella.

In this series, Bonnie (Liza Weil) has an affair with one of the students, Asher, mentored by her and Annalise. As Paris in Gilmore Girls (2000), she had an affair with Rory's lecturer, Asher.

Liza Weil plays a lawyer here who is involved in a case where a pregnant girl ends up dead in the water. In Scandal, it is her her character who ends up pregnant and dead in the water, being associated with a lawyer-cum-fixer, Olivia Pope. Both shows are from Shondaland.