Viola Davis became the first African-American woman to receive an Emmy Award for Outstanding Lead Actress in a Drama Series because of her work on this show. She won in that category in 2015.

The iconic scene where Annalise Keating is wiping off her make up and removing her wig was Viola Davis's idea.

The title of every episode is part of the dialogue from the respective episode.

The series was inspired by the television series Damages (2007) and the movie Legally Blonde (2001) and incorporated some elements of those two mediums for this show.

Annalise (Viola Davis)'s classroom in the pilot is an auditorium at Ursinus College in Pennsylvania. After filming the pilot, it was recreated as a set.

Karla Souza initially auditioned for the role of Michaela Pratt, then Rebecca Sutter before being asked by the show's creator Peter Nowalk to audition for the role of Laurel Castillo.

While on Ellen: The Ellen DeGeneres Show (2003), Viola Davis praised the makeup artists who apply the body makeup for her sex scenes. Davis said that when asked where she wanted makeup applied, She responded, "everywhere."

Viola Davis is an alumna of Juilliard.

Most of Rebecca Sutter (Katie Findlay)'s piercings are fake.

Charlie Weberr (Frank Delfino) and Liza Weil (Bonnie Winterbottom) dated in real life as Charlie said "We were great friends and we found ourselves in a position to be more than that"

Viola Davis and Cicely Tyson both appeared in The Help (2011).

On 3rd January 2018, it was confirmed that How to Get Away With Murder would be doing a crossover episode with another of Shonda Rhimes' shows Scandal (2012).

Matt McGorry and Alysia Reiner previously worked together on Orange Is the New Black (2013).

Viola Davis played a defense lawyer in Law & Order: Special Victims Unit (1999).

Viola Davis is shown defending an alleged killer in Philadelphia's City Hall in How to Get Away with Murder: Pilot (2014). Davis was previously seen working in there when she portrayed the Philadelphia mayor in Law Abiding Citizen (2009).

The name Mr. Darcy derives from Pride and Prejudice's Mr. Darcy

Matt McGorry (Asher Millstone) & Alysia Reiner (D.A. Wendy Parks) also worked together on Orange Is the New Black (2013) as John Bennett & Natalie Figueroa respectively.

Liza Weil (Bonnie Winterbottom) and Wilson Bethel (Charles Mahoney) have both starred in TV shows filmed in the same location. Liza appeared in Gilmore Girls (2000) playing Paris Gellar, while Wilson appeared in Hart of Dixie (2011) playing Wade Kinsella.

Liza Weil (Bonnie) and Amy Okuda (Catherine Hapstall) have appeared in Grey's Anatomy (2005), another show created by Shonda Rhimes.

In this series, Bonnie (Liza Weil) has an affair with one of the students, Asher, mentored by her and Annalise. As Paris in Gilmore Girls (2000), she had an affair with Rory's lecturer, Asher.

Liza Weil plays a lawyer here who is involved in a case where a pregnant girl ends up dead in the water. In Scandal, it is her her character who ends up pregnant and dead in the water, being associated with a lawyer-cum-fixer, Olivia Pope (Kerry Washington). Both shows are from Shonda Rhimes.