Will Forte wrote the role of Carol specifically for Kristen Schaal.

June 17th is marked on the calendar as Phil Miller's (Will Forte's) birthday, which is Forte's actual birthday.

Patti Forte, Will Forte's real-life mother, played Patti Miller in the premiere episode "Alive in Tucson". Patti Miller was the mother of Phil Miller, and was shown during a flashback on one of Phil's past birthdays. In the show, she was explained to have been killed by the virus.

The main character, Phil Tandy Miller, was named after the Executive Producers of the show, Phil Lord and Christopher Miller.

In season one, episode seven, "She Drives Me Crazy", Carol (Kristen Schaal) is stuck with a cow in her house that won't go down a staircase. The same thing happened on Bob's Burgers (2011) season one, episode three, "Sacred Cow", also starring Schaal.

Will Forte and Jason Sudeikis appeared as the hosts of their own separate shows on radio station WKTT in the video game Grand Theft Auto IV (2008).

Jason Sudeikis is shown in a photograph in the pilot episode as Phil's brother. January Jones (Melissa Chartres) had a relationship with Sudeikis in 2010.

In season one, episode six, "Some Friggin' Fat Dude", Melissa mentions that The Shawshank Redemption (1994) is her favorite movie. She later mentions The Godfather (1972) is "like my second favorite movie". Those are the top two rated movies in the IMDb top 250 movies of all time.

Will Forte wrote the role of Pamela specifically for Kristen Wiig.

"Stivers Hardware" comes from Will Forte's mother's maiden name.

Will Forte and Mel Rodriquez appeared in The Watch (2012).

Will Forte and Kristen Schaal appeared in Cloudy with a Chance of Meatballs 2 (2013), as well as the show Gravity Falls (2012).

Phil Miller's middle name is Tandy, and Tandy is a diminutive form of the name Andrew, which is Carol's middle name.

Will Forte and Mel Rodriguez played police partners in The Watch (2012).

Jason Sudekis (Box) and Kristen Schaal (trivia host) had small parts in Going the Distance (2010).

There is no movement during the sex scene between Will and Carol, due to it being on network television.

Will Forte's character's first name is Phil. In That's My Boy (2012), his character's first name was Phil as well.

Phil writing directions on billboards for other survivors to find may have been inspired by the post-apocalyptic novel The Day of the Triffids.

Will Forte, Kristen Schaal, Jason Sudeikis, Mary Steenburgen, and John Hamm appeared on 30 Rock (2006).

Despite the obvious fact of everyone else on earth being dead, and the constant mention of the large numbers of people all the main characters witnessed dying, there are never any dead bodies shown. Presumably the cities and streets would be filled with the corpses of most of the victims of the virus, but none are ever observed.

In season two, Will Ferrell guest starred as Gordon. We later found out that Gail (Mary Steenburgen) dated him in the show. Steenburgen played Ferrell's stepmother in Elf (2003), as well as his mother in Step Brothers (2008).

There's been a recurring gag ever since the beginning of season two, where a famous guest star is brought in and is killed off almost immediately with only one line of dialogue: -Will Ferrell, as Gordon (season two, episode two) died from a heart attack after being scared by Carol. -Jon Hamm, as Daryl (season three, episode one) was shot and killed by Melissa. -Jack Black, as Rear Admiral Roy Billups (season four, episode one) was shot and killed by Pat.