Nathan Drake (voice)
Samuel Drake (voice)
Victor Sullivan (voice)
Elena Fisher (voice)
Rafe Adler (voice)
Nadine Ross (voice)
Jameson (voice)
Vargas (voice)
Hector Alcazar / Atoq Navarro (Multiplayer) / Talbot (Multiplayer) (voice)
Evelyn / Nun (voice)
Young Samuel (voice)
Young Nathan (voice)
Gustavo (voice)
Cassie (voice)
Shoreline Mercenary / Villain Hunter Male Sidekick (voice)
Shoreline Mercenary / Villain Brute Male Sidekick (voice)
Shoreline Mercenary (voice)
Shoreline Mercenary / Orca (Multiplayer) (voice)
Shoreline Mercenary / Additional Voices (voice)
Shoreline Mercenary (voice) (as Ade M'Cormack)
Additional Voices (voice)
Additional Voices (voice) (as John Bentley)
Additional Voices (voice) (as Sevy Di Cicone)
Additional Voices (voice) (as Mohamed Dione)
Additional Voices (voice) (as Mike Estime)
Additional Voices (voice) (as Amy Pemberton)
Katherine Marlowe (Multiplayer) (voice)
Rameses (Multiplayer) (voice)
Additional Multiplayer Voices (voice)
Roberto Guerrero (Multiplayer) (voice)
Tenzin (Multiplayer) (voice)
Additional Multiplayer Voices (voice) (as Lauren Mayhew)
Salim (Multiplayer) (voice) (as TJ Ramini)
Eddy Raja (Multiplayer) (voice)
Gabriel Roman (Multiplayer) (voice)
Cassie Drake (voice)
Jameson (voice) (as Mitsura Ogata)
Nathan Drake (young) (voice)
Hector Alcazar (voice)
Evelyn (voice)
Nathan Drake (voice) (as Hiroki Touchi)
Samuel Drake (young) (voice) (as Koki Uchiyama)
Crash Bandicoot (archive sound) (uncredited)