Set three years after his last adventure, Nathan Drake has now settled down with his wife, Elena Fisher and left the treasure hunting scene behind. That all changes, however, when Nate's long thought-to-be dead brother, Sam tracks him down, and asks for his help to find the long lost treasure of Pirate Captain Henry Avery. Together with Sully, Nate and Sam embark on a globe-trotting adventure, one last time.