- Severe
- Cocaine, heroin, marijuana, DMX, horse tranquillisers, xanax and all sorts of pills are consumed throughout the show, some usage shown graphically, some times just implied.
- Frequent paraphernalia.
- In the episode 'Love and/or Marriage' (S3 EP5) several people are seen taking this drug called 'gush', a sort of acidic opiate pill, the consequent hallucinations are seen.
- BoJack is a severe alcoholic, and is shown drinking constantly throughout the six seasons of the show.
- In season three, it is discovered that the name 'BoJack' is also a popular heroin brand. BoJack is also shown snorting heroin of that patent in one of season three's final episodes.
- One of the season two's final episodes shows a teenage girl getting progressively drunk and eventually succumbing to alcohol poisoning.
- In the second episode of season three, two characters start drinking to write a script for a new TV show, eventually they get drunk and start writing nonsense.
- Frequent and graphic drinking. Cigarette smoking throughout. Occasional marijuana smoking. Occasional cocaine use. Prescription opiates are used. There is also heroin use, and a scene where a woman takes a fictional drug ("Gush") that is described as being similar to LSD and MDMA. There are also many scenes of characters taking and snorting pills
- There are implications regarding drug use in almost every episode, where characters will passingly remark on situations/incidents or other characters in conjunction with drug use, and some episodes feature actual drug use being depicted by various characters in the series. Pills and other forms of drug paraphernalia can be seen in the background occasionally in almost every episode as well.
- One of BoJack's former co-stars is a serious addict and throughout the show she is seen consuming countless amounts of drugs and alcohol.
- BoJack is a welcomer to alcoholism and drinks different forms of alcohol (e.g. bourbon, whiskey, tequila, etc.) in almost every episode. He drinks from a flask frequently, at one point is shown drinking a few consecutively in a flashback. (In the series opening title, BoJack is depicted getting drunk at a party, at one point holding a glass of alcohol, then stumbling over the edge of his penthouse into his pool.)
- BoJack is also a frequent cigarette smoker and is shown passively smoking a cigarette in several episodes, obviously under a nicotine addiction.
- Various characters, other than BoJack, are also seen drinking alcohol and getting adversely drunk in some episodes.
- [Season 1]
- There are different depictions of drug use in this season, including one long, somewhat excessive portrayal of drug use and the effects of drug use covering an entire episode.
- When BoJack meets his former co-star in 'Episode 3', she is implied to be under the effects of drugs constantly, and at one point, does handful of pills. BoJack then questions her whether that is the appropriate way to consume prescription drugs.
- BoJack is severely intoxicated off-screen in 'Episode 6', so much that he steals the 'D' work from the 'Hollywood' sign. Only the aftermath is show, and his intoxication is only discussed.
- BoJack is shown very intoxicated in a couple of episodes, with many beer cans surrounding him.
- A race figure that BoJack looked up to during his childhood years is implied to have taken steroids and testosterone-enhancing drugs after he is revealed to have cheated on the racetrack.
- A young boy asks BoJack's agent, disguised as a man in a trench-coat, 'Would you like a alcohol?'
- [Season 2]
- One of BoJack's friends, at one point, gives up on her life temporarily and sleeps at his house, to which she becomes increasingly lazy and frequently consumes beer. She eventually brings him into her psyche, and they drink a horrendous amount of beer, at one point organizing the empty beer cans into various monuments offscreen. They also smoke marijuana together.
- At one point in the same episode, while BoJack passively talks to his annoyed girlfriend, he and his friend smoke from a bong somewhat offscreen. One closeup shows his friend lighting the bong and smoking with bubbles heard.
- In one episode, a disturbing flashback shows BoJack, as a kid, sneaking a cigarette packet from his mother's purse and taking one out and smoking it, to his discomfort, before his mother comes in and marks her indifference to his actions, instead showing her disappointment in his existence, and forces him to finish the cigarette. This scene is sad, disturbing and very distressing.
- One of the episodes features BoJack smoking a joint in a close-up very briefly.
- BoJack's golden retriever friend is shown wearing a dog cone in 'Episode 1', after he could not stop biting his stitches due to him punching a mirror in a drunken stupor. This is only discussed.
- In the third season, BoJack takes a 9-month-sober Sarah Lynn on a bender. Together they take different narcotics and drink copious amounts of alcohol. Unfortunately, after snorting heroin, the frighteningly young Sarah Lynn dies of an overdose.
- In season five, BoJack injures his back badly and gets prescribed painkillers. He gradually starts getting more and more addicted to them, so much so as to fully loose consciousness, and even purposely getting into a car crash so that he can get them prescribed again.
- A young Bojack is forced to smoke an entire pack of cigarettes as punishment for stealing one from his mother.
- It is heavily implied that BoJack's mother (Beatrice) was forced to take weight-loss supplements as a child, and in a shocking twist it is discovered that she would drug Hollyhock's coffee with them, so that she would loose weight.
- BoJack, at one point, drives to New Mexico and decides to live with his long-lost friend and her family. When he brings her daughter and her friends to prom in her car, he sees one of them drinking from a flask, and when he confiscates it and tastes it, he remarks that 'whiskey and Red Bull' have high sugar content, and proposes that he get them bourbon and mix it with water instead. He then states that if they wish to drink, they should do so 'responsibly.' One of the friends eventually becomes more sluggish in her state of intoxication and passes out in a desert, needing to be taken to the hospital.