Steve Carell said that Despicable Me 3 (2017) may be his last film as the voice of Gru. However, Carell stated that if he was asked to do a cameo in any future Minion sequels, he happily would.

Agnes's voice actress Elsie Fisher from the first and second movies was replaced by Nev Scharrel due to Fisher getting too old for the role.

The diamond featured in the first trailer is a parody to the Pink Panther diamond.

The country that Dru lives in and Gru originates from is the fictional European country of Freedonia. This is the same name as a similar fictional European country in the Marx brothers' movie Duck Soup (1933).

Trey Parker's first role in a movie targeted to children.

Margo's shirt has The Grinch on it. This is a reference to Illumination's next film.

In September 2017, this film grossed a billion dollars worldwide, becoming the only film released in Summer 2017 to do so, and also becoming the year's 3rd highest grossing film.

In the prison, minions collect valuables from the prisoners, one of them is Mr. Bean (1990) teddy.

Though Dr. Nafario can be seen in a flashback, he remains silent. This makes it the first Despicable Me film to not feature Russell Brand voicing said character.

At the talent show, the Minions sing in Minionese "I Am the Very Model of a Modern Major General" from The Pirates of Penzance by Gilbert and Sullivan.

The animated sequence at the first part of the end credits, in which Dru & Gru are trying to outdo one another, is a reference to the opening credits sequences of the classic Pink Panther movies.

John Cygan's final role.

When Dru reaches into the power supply of the robot, the mechanism he pulls out is remarkably similar to the flux capacitor from "Back to the Future".

Alan Tudyk was considered for the role of Balthazar Bratt.

This is the first Illumination Entertainment film to be produced in a 2.39:1 widescreen aspect ratio; all of that company's previous films before this one, plus the previous Despicable Me films, were produced in the taller 1.85:1 aspect ratio.

In France, the voices for the twins Gru and Dru are performed by Gad Elmaleh and Arié Elmaleh who are brothers in real life.

Steve Carell, Miranda Cosgrove, Dana Gaier, and Pierre Coffin are the only actors to reprise their roles for all three films. However, along with said characters, Kristen Wiig is also one of the few actors to be in all three films as she voiced Miss Hattie from Despicable Me (2010).

Shipped to cinemas under the Pseudonym "Double Bubble"

Jenny Slate's third Illumination Entertainment film after The Lorax (2012) and The Secret Life of Pets (2016).

Near the start of the film as Gru and Lucy are racing to the ship in mini subs, they show two clown fish with one looking bigger then the other. One of the subs then hits the smaller one and all we see that is left is that fish's fin. This is most like a reference to the "Finding Nemo" movies as Nemo had a bad fin.

The second Illumination Entertainment film to be rated PG for action and rude humor by the MPAA, after Minions (2015).

In one scene in Gru's lair the Minions are standing in front of a big computer machine with a green screen. The screen is actually displaying the Page R (the music sequencer screen) from a Fairlight CMI synthesiser series II which cost around £30,000 when originally launched back in 1982. It is unclear from the brief appearance in the movie what is being played back on the screen.

The film opened in a record 4,529 theaters on June 30, 2017.

The costumes Gru & Dru wear are reminiscent of classic 1960s Italian comic series Diabolik, who is a ruthless master thief and typically steals from criminals.

The film has 5 Academy Award nominees: Steve Carell, Kristen Wiig, Trey Parker, Steve Coogan and Pierre Coffin

This is the first film to have the Illumination Entertainment logo simply read "Illumination".

Balthazar Bratt's name is probably a reference to actor Benjamin Bratt who previously voiced the villain, El Macho, from the previous film Despicable Me 2 (2013).

The song the Minions sing in the singing competition, "I Am the Very Model of a Modern Major-General", is from Gilbert and Sullivans 1879 comic opera "The Pirates of Penzance". The competition is obviously a nod the the various singing reality shows like "American Idol" and "X-Factor".

The first Despicable Me film to not be nominated for the Golden Globe for Best Animated Feature.

Agnes has a mobile over her bed that resembles an Alexander Calder in the shape of a minion.

John Cena, Ty Burrell, Ed Helms, Ed O'Neill, Josh Gad, Bill Hader, Danny McBride, Steve Zahn, Andy Samberg, Ashton Kutcher, Will Forte, Bruce Willis and John Malkovich were all considered for the role of Balthazar Bratt.

Illumination's 8th feature film.

The second Illumination film and sixth animated film to gross a billion dollars worldwide.

The last Illumination Entertainment film to have the credits of IATSE.

When Bratt stomps on the Hollywood sign, he leaves the first 3 letters alone, so it just says, "HOL" - there was a game in the 80s called "Human Occupied Landfill," and the cover of the book just said HOL.

The museum director Balthazar Bratt is dressed up as bears a strong resemblance to Mayor Shelbourne, the gluttonous and egotistical mayor from Cloudy with a Chance of Meatballs (2009).

This film will feature Balthazar Bratt as the new villain. Other villains in the Despicable Me franchise have been Vector, El Macho, and Scarlet Overkill. Voiced by Jason Segel, Benjamin Bratt, and Sandra Bullock respectively.

From Illumination Creators of Minions (2015) and The Secret Life of Pets (2016).

Jenny Slate's 3rd Universal film after The Lorax (2012) and The Secret Life of Pets (2016).

Bratt's giant robot resembles the children from Trey Parker's (Bratt's voice actor) show South Park.

Jenny Slate's 5th animated film, after The Lorax (2012), Zootopia (2016), The Secret Life of Pets (2016) and The LEGO Batman Movie (2017).

When the giant Bratt robot is attacking Hollywood, K.I.T.T. from Knight Rider (1982) can be seen reversing away.

When Mel and the other minions are roaming the streets there is a poster for a TV show called SING!, this is a reference to another film made by illumination

There are two posters titled "onions" as a parody to the minions poster. These can be seen towards the end in the Hollywood studios

The army of Bratt dolls that Balthazar Bratt sends to kill Gru are referred to as 'the Bratt pack' this is a clear reference to the name given by the media, to a group of 80s actors, popular for films such as ' The Breakfast Club' and 'St Elmo's Fire'.

When Professor Nefario accidentally freezes himself, it is a reference to Star Wars.

When Lucy uses a helicopter to rescue Gru, Dru, and the diamond from Bratt's lair, this is likely a reference to the Beatles song "Lucy in the Sky With Diamonds."

At the end of this film, Lucy Wilde is left tied up and gagged in a closet. At the end of the previous film Despicable Me 2 (2013), she was also tied up and strapped to a rocket.