Steve Carell said that Despicable Me 3 (2017) may be his last film as the voice of Gru. However, Carell stated that if he was asked to do a cameo in any future Minion sequels, he happily would.
Agnes' voice actress Elsie Fisher from the first and second movies was replaced by Nev Scharrel due to Fisher getting too old for the role.
The diamond featured in the first trailer is a parody of the "Pink Panther" diamond.
The country that Dru lives in and Gru originates from is the fictional European country of Freedonia. This is the same name as a similar fictional European country in The Marx Brothers' movie Duck Soup (1933).
Margo's shirt has The Grinch on it. This is a reference to Illumination's next film.
In the prison minions collect valuables from the prisoners, one of them is Mr. Bean (1990) teddy.
Though Dr. Nafario can be seen in a flashback, he remains silent. This makes it the first "Despicable Me" film to not feature Russell Brand voicing that character.
In September 2017 this film grossed $1 billion worldwide, becoming the only film released in Summer 2017 to do so, and also becoming the year's third highest grossing film.
When Dru reaches into the power supply of the robot, the mechanism he pulls out is remarkably similar to the flux capacitor from "Back to the Future (1985).
The animated sequence at the first part of the end credits, in which Dru and Gru are trying to outdo one another, is a reference to the opening credits sequences of the classic "Pink Panther" movies.
Near the start of the film as Gru and Lucy are racing to the ship in mini subs, they show two clown fish, with one looking bigger than the other. One of the subs then hits the smaller one and all we see that is left is that fish's fin. This is most like a reference to the "Finding Nemo" movies, as Nemo had a bad fin.
Steve Carell, Miranda Cosgrove, Dana Gaier and Pierre Coffin are the only actors to reprise their roles in all three films. However, along with said characters, Kristen Wiig is also one of the few actors to be in all three films, as she voiced Miss Hattie from Despicable Me (2010).
This is the first Illumination Entertainment film to be produced in a 2.39:1 widescreen aspect ratio; all of the company's previous films, plus the previous "Despicable Me" films, were produced in the taller 1.85:1 aspect ratio.
In France the voices for the twins Gru and Dru are performed by Gad Elmaleh and Arié Elmaleh, who are brothers in real life.
In one scene in Gru's lair the Minions are standing in front of a big computer machine with a green screen. The screen is actually displaying the Page R (the music sequencer screen) from a Fairlight CMI synthesiser series II which cost around £30,000 when originally launched back in 1982. It is unclear from the brief appearance in the movie what is being played back on the screen.
The song the Minions sing in the singing competition, "I Am the Very Model of a Modern Major-General", is from W.S. Gilbert and Arthur Sullivan's 1879 comic opera "The Pirates of Penzance". The competition is obviously a nod to the various singing reality shows like "American Idol" (2002) and "The X-Factor" (2011).
The first "Despicable Me" film to not be nominated for the Golden Globe for Best Animated Feature.
The costumes Gru and Dru wear are reminiscent of the classic 1960s Italian comic series "Diabolik", who is a ruthless master thief and typically steals from criminals.
Agnes has a mobile over her bed that resembles an Alexander Calder in the shape of a Minion.
The second Illumination Entertainment film to be rated PG for action and rude humor by the MPAA, after Minions (2015).
This is the first film to have the Illumination Entertainment logo simply read "Illumination".
The film has five Academy Award nominees: Steve Carell, Kristen Wiig, Trey Parker, Steve Coogan and Pierre Coffin
The second Illumination film and sixth animated film to gross a billion dollars worldwide.
The museum director Balthazar Bratt is dressed up as bears a strong resemblance to Mayor Shelbourne, the gluttonous and egotistical mayor from Cloudy with a Chance of Meatballs (2009).
Balthazar Bratt's name is likely a reference to Benjamin Bratt, who previously voiced the villain, El Macho, from the previous film Despicable Me 2 (2013).
John Cena, Ty Burrell, Ed Helms, Ed O'Neill, Josh Gad, Bill Hader, Danny McBride, Steve Zahn, Andy Samberg, Ashton Kutcher, Will Forte, Bruce Willis and John Malkovich were all considered for the role of Balthazar Bratt.
With this film and Minions (2015), the Despicable Me movie series became the first animated franchise to have two movies earn a billion dollars in the box office.
This film features Balthazar Bratt as the new villain. Other villains in the "Despicable Me" franchise have been Vector, El Macho and Scarlet Overkill--voiced by Jason Segel, Benjamin Bratt and Sandra Bullock respectively.
When Bratt stomps on the Hollywood sign, he leaves the first three letters alone, so it just says, "HOL". There was a game in the 1980s called "Human Occupied Landfill," and the cover of the book just said HOL.
Bratt's giant robot resembles the children from Trey Parker's (Bratt's voice actor) show "South Park" (1997).