Steve Carell said that Despicable Me 3 (2017) may be his last film as the voice of Gru. However, Carell stated that if he was asked to do a cameo in any future Minion sequels, he happily would.

Agnes' voice actress Elsie Fisher from the first and second movies was replaced by Nev Scharrel due to Fisher getting too old for the role.

The diamond featured in the first trailer is a parody of the "Pink Panther" diamond.

Margo's shirt has The Grinch on it. This is a reference to Illumination's next film.

The country that Dru lives in and Gru originates from is the fictional European country of Freedonia. This is the same name as a similar fictional European country in The Marx Brothers' movie Duck Soup (1933).

In September 2017 this film grossed $1 billion worldwide, becoming the only film released in Summer 2017 to do so, and also becoming the year's third highest grossing film.

Though Dr. Nafario can be seen in a flashback, he remains silent. This makes it the first "Despicable Me" film to not feature Russell Brand voicing that character.

In the prison minions collect valuables from the prisoners, one of them is Mr. Bean (1990) teddy.

When Dru reaches into the power supply of the robot, the mechanism he pulls out is remarkably similar to the flux capacitor from "Back to the Future (1985).

Final film of John Cygan.

The animated sequence at the first part of the end credits, in which Dru and Gru are trying to outdo one another, is a reference to the opening credits sequences of the classic "Pink Panther" movies.

Steve Carell, Miranda Cosgrove, Dana Gaier and Pierre Coffin are the only actors to reprise their roles in all three films. However, along with said characters, Kristen Wiig is also one of the few actors to be in all three films, as she voiced Miss Hattie from Despicable Me (2010).

This is the first Illumination Entertainment film to be produced in a 2.35:1 widescreen aspect ratio; all of the company's previous films, plus the previous "Despicable Me" films, were produced in the taller 1.85:1 aspect ratio.

In France the voices for the twins Gru and Dru are performed by Gad Elmaleh and Arié Elmaleh, who are brothers in real life.

The first "Despicable Me" film to not be nominated for the Golden Globe for Best Animated Feature.

Shipped to cinemas under the Pseudonym "Double Bubble"

Alan Tudyk was considered for the role of Balthazar Bratt.

The film opened in a record 4,529 theaters on June 30, 2017.

The costumes Gru and Dru wear are reminiscent of the classic 1960s Italian comic series "Diabolik", who is a ruthless master thief and typically steals from criminals.

The song the Minions sing in the singing competition, "I Am the Very Model of a Modern Major-General", is from W.S. Gilbert and Arthur Sullivan's 1879 comic opera "The Pirates of Penzance". The competition is obviously a nod to the various singing reality shows like "American Idol" (2002) and "The X-Factor" (2011).

In one scene in Gru's lair the Minions are standing in front of a big computer machine with a green screen. The screen is actually displaying the Page R (the music sequencer screen) from a Fairlight CMI synthesiser series II which cost around £30,000 when originally launched back in 1982. It is unclear from the brief appearance in the movie what is being played back on the screen.

The second Illumination Entertainment film to be rated PG for action and rude humor by the MPAA, after Minions (2015).

This is the first film to have the Illumination Entertainment logo simply read "Illumination".

Agnes has a mobile over her bed that resembles an Alexander Calder in the shape of a Minion.

The film has five Academy Award nominees: Steve Carell, Kristen Wiig, Trey Parker, Steve Coogan and Pierre Coffin

The second Illumination film and sixth animated film to gross a billion dollars worldwide.

With this film and Minions (2015), the Despicable Me movie series became the first animated franchise to have two movies earn a billion dollars in the box office.

John Cena, Ty Burrell, Ed Helms, Ed O'Neill, Josh Gad, Bill Hader, Danny McBride, Steve Zahn, Andy Samberg, Ashton Kutcher, Will Forte, Bruce Willis and John Malkovich were all considered for the role of Balthazar Bratt.

This film features Balthazar Bratt as the new villain. Other villains in the "Despicable Me" franchise have been Vector, El Macho and Scarlet Overkill--voiced by Jason Segel, Benjamin Bratt and Sandra Bullock respectively.

The last Illumination Entertainment film to have the credits of IATSE.

When Bratt stomps on the Hollywood sign, he leaves the first three letters alone, so it just says, "HOL". There was a game in the 1980s called "Human Occupied Landfill," and the cover of the book just said HOL.

Bratt's giant robot resembles the children from Trey Parker's (Bratt's voice actor) show "South Park" (1997).

Jenny Slate's fifth animated film, after The Lorax (2012), Zootopia (2016), The Secret Life of Pets (2016) and The Lego Batman Movie (2017).

From Illumination Creators of Minions (2015) and The Secret Life of Pets (2016).

Bratt's lair seems to contain obvious references to the Neon Mix Tape level of the video game Plants vs Zombies 2. Notice the yellow video arcade consoles, the floor with squares outlined in a lighted grid, the yellow-wheeled roller skates, the large speakers, the keytar, the boombox, and the triangle-shaped decorations.

The second Universal's animated film to be produced in 2.35:1, after The Tale of Despereaux (2008).

Mel the minion is bald on top, with hair around the back and sides. Considering the producers' interest in the 1960s, as seen in Minions (2015), it is likely that this Minion was named after the similarly balding character Mel Cooley Richard Deacon from the The Dick Van Dyke Show (1961).

The eighth Illumination film to be rated PG by the MPAA, after Despicable Me (2010), Hop (2011), The Lorax (2012), Despicable Me 2 (2013), Minions (2015), The Secret Life of Pets (2016) and Sing (2016).

When the giant Bratt robot is attacking Hollywood, K.I.T.T. from Knight Rider (1982) can be seen reversing away.

There are two posters titled "onions" as a parody of the Minions poster. These can be seen towards the end in the Hollywood studios

When Mel and the other Minions are roaming the streets there is a poster for a TV show called SING!, this is a reference to another film made by illumination.

The army of Bratt dolls that Balthazar Bratt sends to kill Gru are referred to as "the Bratt pack". This is a clear reference to the name given by the media, to a group of 1980s actors, popular for films such as The Breakfast Club (1985) and St. Elmo's Fire (1985).

When Lucy uses a helicopter to rescue Gru, Dru and the diamond from Bratt's lair, this is likely a reference to The Beatles' song "Lucy in the Sky With Diamonds."

At the end of this film, Lucy Wilde is left tied up and gagged in a closet. At the end of the previous film Despicable Me 2 (2013), she was also tied up and strapped to a rocket.