Russell Hodgkinson, who played Doc, found a host family in Spokane, Washington. He lived in their basement throughout the filming of the second season, doing interior painting and yard work in exchange for free rent.
The first season was recorded on a tight schedule, with an episode being fully recorded within six days, with most shoots only allowing three takes.
Several of the actors/crew lived together while filming the first season in Spokane, Washington, to save on costs. This included Anastasia Baranova (Addy) and Michael Welch (Mack).
Keith Allan (Murphy) was working for The Asylum production company as a stage hand when they were tasked with Z Nation (2014). They suggested he audition for the role of Murphy and he ended up getting the part.
As the character of Murphy continued to evolve, it was decided that the blue skin aspect of the character would be removed. This was largely due to the fact that the makeup itself was extremely irritating to actor Keith Allan, causing some minor skin complications as he had no choice but to wear the make up sometimes over 12 hours a day during filming.