Since the death of Don Adams, this is the first animated Gadget not to be voiced by Maurice Lamarche.

In a couple of episodes , Penny is briefly seen wearing the same shirt and pants that she wore in the original series.

Despite the name of the show, Penny is effectively the protagonist.

Unlike in the original series, MAD Cat is female.

Because Penny is more active and willing to put up a fight, she doesn't end up getting captured by a MAD agent, like in the original series.

Professor Von Slickstein is portrayed as a young man in this series, while in the original, he was in his late '60s.