Following an angry response from some audience members at the January 2016 Sundance premiere, a few festival reviewers purposefully spoiled the film in detail so as to deter animal lovers from seeing the film.

Heather Matarazzo turned down a possibility to reprise her role of Dawn Wiener from Welcome to the Dollhouse (1995). She was replaced by Greta Gerwig.

Brie Larson had filmed a scene for the film, but it was deleted from the final cut.

According to director Todd Solondz, the title character was portrayed by four dachshund show dogs but personally found them to be "dumb".

Keaton Nigel Cooke learned "Clair De Lune" by Debussy on flute for a scene in less than one week.

Keaton Nigel Cooke is the only lead actor with two movies in this year's Sundance Film Festival (2016).

Wiener-Dog has won the Best Film Award at the 2017 LongTake Interative Film Festival #LIFF2017 in Milan, Italy, July 7-9. Films in competition are selected from titles yet unreleased in Italian movie theaters. The winner is chosen by people attending the screenings.

At the Sundance premiere, the final gory segment of the movie in which the dog is repeatedly run over in the street garnered a large walkout with booing from the festival audience with just minutes left in the movie.