This movie is based on a graphic novel that co-Director Scott Christian Sava wrote for his two children.

Emily Blunt and John Krasinski, who play a married couple, Zoe and Owen, are married in real-life as well.

The film almost never came out because it was held up for almost a year due to a lawsuit by a Seattle fisherman named Rodger May who claimed he owned the copyright to the film. The lawsuit was eventually withdrawn. All records of the lawsuit are public and can be found by a search for "Mayday vs. Animal Crackers".

This movie was originally intended to be released on April 27, 2017 by Relativity Media, before they went defunct. It then set to be released on September 1, 2017 by upstart film company Serafini Releasing before they also shut down. This movie was later acquired by Entertainment Studios Motion Pictures, but the producers have since come out from that deal. It's now slated for release on August 30, 2019 in the U.S. (as of March 2019).

Mackenzie's toy monkey is the monkey from Cloudy With a Chance of Meatball's.

Kaley Cuoco was originally slated to play Zoe, but due to scheduling issues, she was replaced with Emily Blunt.

The pizza truck that is featured in the chase scene is that of Joey's House of Pizza, a local Nashville pizza establishment.

Although finished in 2017, the film holds a copyright date of 2019.

Patrick Warburton's second time voicing an animated character by the name of "Brock". The first being bodyguard "Brock Samson" in the animated show The Venture Bros. (2003).

Justin Timberlake, Jason Bateman, Joseph Gordon-Levitt, Jimmy Fallon, Ryan Reynolds, Neil Patrick Harris, Bryan Cranston, and Jason Segel were all considered for the role of Owen.

Robin Williams was initially cast as Chesterfield, but his death resulted in Danny DeVito being cast. DeVito had previously directed Williams in Death to Smoochy (2002).

Sir Ian McKellen's 5th voice acting performance in a theatrical movie, after Flushed Away (2006), The Golden Compass (2007), Beauty and the Beast (2017), and Doogal.

Danny DeVito and Emily Blunt appeared in theatrical "My Little Pony" movies. DeVito was in My Little Pony: The Movie (1986) and Blunt was in My Little Pony: The Movie (2017).

When Owen and Binkley are trying to start the biscuit machine, Binkley suggests pressing up, up, down, down, left, right, left, right, A, B, start. This is The Konami Code. The famous cheat code built in to old school Konami video games.

Jeff Bridges, Al Pacino, Kurt Russell, Kevin Spacey, John Lithgow, Patrick Stewart, Willem Dafoe, Kelsey Grammer, Mark Hamill, and Michael Douglas were all once considered for the role of Horatio, coincidentally three of these actors previously had their parts in Pixar films Spacey in A Bug's Life (1998), Grammer in Toy Story 2 (1999), and Dafoe in the Finding Nemo films.

Maya Rudolph, Nicki Minaj, Rashida Jones, Keke Palmer, and Taraji P. Henson were considered for the role of Binkley.

The guitar shown in The "Don't stop me now" scene is very accurately modeled after Queen guitarist Brian May's "Red Special". His main guitar, that was build by May and his father. Only the color differs. The song that carries the scene is of course "Don't stop me now" by Queen.

Dwayne "The Rock" Johnson was considered for the role of Bullet-Man.

John Krasinski's fourth animated movie, after Shrek the Third (2007), Monsters vs. Aliens (2009), and Monsters University (2013). It's also Krasinski's first animated movie that does not have him playing a minor character who appears in only one scene.

Shakira, Joan Cusack, Drew Barrymore, Tina Fey, Uma Thurman, Gwen Stefani, Gwyneth Paltrow, Kate Beckinsale, Mindy Kaling, Shania Twain, Carrie Underwood, and Miranda Lambert were considered for the role of Zoe.

The actual name of the cookie product is "Barnum's Animals Crackers" with an "s" at the end of animal, not "Animal Crackers". Some attribute this misremembering to the Mandela Effect, or they're thinking of Stauffer's Animal Crackers.

Tara Strong and Emily Blunt appeared in My Little Pony: The Movie (2017).

John Leguizamo was considered for the role of Mario Zucchini.

Mel Brooks, Billy Crystal, Nathan Lane, Jim Carrey, Sir Michael Caine, Morgan Freeman, Christopher Walken, and Martin Short were considered for the role of Chesterfield.

This is the fourth animated movie, for which Sylvester Stallone has provided a voice.

Mandy Moore was considered for the role of Zoe.

The main story takes place in Franklin, Tennessee, the hometown of the original graphic novel's author Scott Christian Sava.

When Zucchini flies into the manure farm, it's named B Tannen manure farm like Biff Tannen from Back to the Future.

Wallace Shawn's first theatrically released animated movie that's not from Disney since Happily N'Ever After (2007).

James Arnold Taylor and Sylvester Stallone appeared in Ratchet & Clank (2016).

Emily Blunt and John Krasinski appeared in A Quiet Place (2018).

Zucchini's motorbike and helmet are covered in Jack Skellington motif's from Nightmare Before Christmas.

Robert Huntington (Buffalo Bob's full name) is also, according to some sources, the real name of Robin Hood.

Rob Riggle was considered for the role of Brock.

The movie features music by Michael Buble, who was in a long term relationship with Emily Blunt, before she married John Krasinski

The combination Binkley says, "up, up, down, down, left, right, left, right, A, B, start" is a reference to the "Contra code" for the NES.

Danny DeVito's 2nd fully cgi film.

Gilbert Gottfried's third theatrically released animated film after Aladdin (1992) and Thumbelina (1994), as well as his first fully cgi one.

In the movie finale, Zoe turns in to an elephant to save the circus, led by Danny Devito. In Dumbo, Danny Devito's circus is saved by the eponymous elephant.