Ruth Negga and Dominic Cooper, a couple in real life, got into the show together. Negga was preparing her audition for Tulip and asked Cooper to help her prepare. He then read the screenplay and got so interested that started reading the comic books and eventually asked to audition himself for Jesse.

The fourth recent TV show based on a Vertigo property, the other three being Constantine (2014), iZombie (2015), and Lucifer (2015).

Based on the DC Vertigo comic series "Preacher" by Garth Ennis and Steve Dillon.

The actress playing Tulip, Ruth Negga, is Irish (although born in Ethiopia). Ironically, the only Irish character, Cassidy the vampire, is being played by an English actor, Joseph Gilgun.

At one point in the early 2000s Garth Ennis, writer of the Preacher comic series, approached Kevin Smith and Scott Mosier to help finance the film under their View Askew Productions label. Garth Ennis, Kevin Smith and Scott Mosier pitched Preacher to Bob Weinstein at Miramax Films.

Both Joseph Gilgun and Ruth Negga appeared in popular U.K. superhero drama Misfits (2009). Negga played Nicki for 6 episodes, whereas Gilgun was a main cast member from the 3rd series up until its cancellation in 2013 (appearing in 25 episodes overall).

When Ennis and Dillon were doing the original comics from Vertigo (mature imprint of DC comics) it is believed that they got away with more violence and gore than was allowed back in the day because of the initial black and white pages they handed to their editor. All the gore and such were added later on in the process of making the comics.

Anatol Yusef and Garth Ennis, the author of the original comic book series, used to be neighbors.

While set in Texas, it is actually filmed in Albuquerque, New Mexico.

Ruth Negga appeared as Raina in Marvel's Agents of S.H.I.E.L.D. (2013). Dominic Cooper also appeared as the Marvel character Howard Stark in Captain America: The First Avenger (2011) and Agent Carter (2015).

Dominic Cooper and Ruth Negga are playing the royal couple of Azeroth - King Llane and Lady Taria - in Warcraft: The Beginning (2016).

Season 2 will feature 13 episodes instead of 10 episodes that aired in Season 1.

The End-Titles music is the same as on The Blacklist. It's the same music in a slightly different arrangement.

Lucas Neff was cast and even filmed a few scenes as JJ Quincannon, before his character was cut from the series.

The gun that the Saint of killers uses is a Black powder revolver.

Justin Prentice's character, Tyler, states that he is in hell for date rape. In the series "Thirteen Reason's Why" Prentice's character is also guilty of date rape.

The actors that portray Jesse Custer and Young Jesse Custer both share the same first name: Dominic.

Ruth Negga plays a character in Marvel's Agents of S.H.I.E.L.D. (2013) occasionally referred to as Flowers, while her character in Preacher's name is Tulip.

Has been confirmed for a season 3, which is set to air in 2018

Ruth Negga, who plays Tulip O'Hare in this DC comic adaptation, has also appeared in a Marvel comic project. She had a recurring role on Agents of S.H.I.E.L.D. (2013) as the villainous Raina for 17 episodes. Negga also played Nikki in Misfits (2009), a Channel 4 original production based around people with super powers.

Lucy Griffiths (Emily) starred in the pilot of Constantine, another DC Vertigo based comic book adaptation and also the same producers of Preacher.

Jesse Custer is an anagram of "Secret Jesus".

There's a reference to Breaking Bad (2008) in episode 9. The pick up point (dam) for the angels is the same pick up point for the characters in Breaking Bad when they may want to start over again. Additionally, when the van drives away, a shaggy dog crosses the street behind it. A similar visual happens at the end of the Breaking Bad episode "Ozymandias" under similar circumstances.

In Episode Eight "Finish The Song" Angels Fiore and Deblanc, while purchasing their tickets to Hell, encounter a travel agency office very similar to Norman Bates in 'Psycho'. A short while later in the same episode, Emily is seen watching the afore mentioned movie 'Psycho'.

The second time Noah Taylor has portrayed Adolf Hitler, the first time being the film Max (2002), in which he played Hitler during his time as an art student. Ironically enough, Hitler's personal hell in Preacher (2016) appears to involve his failed art career.