This movie was going to be released on September 21, 2018, but it was pushed forward two months to allow Goosebumps: Haunted Halloween (2018) to take that date, though that film would later be pushed back a month to October 12th the same year.

Like with Hotel Transylvania 2 (2015), Keegan-Michael Key replaces CeeLo Green as the voice of Murray, due to Green's arrest. This marks Key's fourth consecutive year in a Sony Animation film, after Hotel Transylvania 2 (2015) as Murray the Mummy, The Angry Birds Movie (2016) as Bird Island's Judge, and The Star (2017) as Dave the Dove.

Andy Samberg's fifth Sony Animation movie after Cloudy with a Chance of Meatballs (2009), Hotel Transylvania (2012), Cloudy with a Chance of Meatballs 2 (2013), and Hotel Transylvania 2 (2015).

Sony Animation's first theatrical threequel. This does not include Open Season 3 (2010), as that film was released straight to DVD, same said for Smurfs: The Lost Village (2017), which was a failed CGI reboot of the franchise.

First Trailer was shown the same day as the release of The Star (2017), another film by Sony Animation.

3rd Collaboration between Keegan-Michael Key and Andy Samberg, after Hotel Transylvania 2 (2015) and Storks (2016).

Like with Hotel Transylvania 2 (2015) which released the same year as Jurassic World (2015), Hotel Transylvania 3: Summer Vacation (2018) released the same year as it's sequel Jurassic World: Fallen Kingdom (2018).

Like with the first Hotel Transylvania (2012) which released the same year as Disney's Wreck-It Ralph (2012), Hotel Transylvania 3: Summer Vacation (2018) released the same year as it's sequel Ralph Breaks the Internet: Wreck-It Ralph 2 (2018). And though there was no Wreck-It Ralph film releasing the same year as Hotel Transylvania 2 (2015), it did release the same year as another Video Game Themed film, being Pixels (2015), which was also distributed by Columbia (the distributor of Sony Animation films).

Like with Hotel Transylvania (2012) which released the same year as The Lorax (2012), Hotel Transylvania 3: Summer Vacation (2018) released the same year as fellow CGI Dr. Seuss film The Grinch (2018).

Director Genndy Tartakovsky replaces Jonny Solomon for providing Blobby's blob talk, making Blobby to be the second character in the series to be recast at some point, following Murray.

First animated film for Kathryn Hahn, though she had previously done a good amount of voice over work in Animated TV Shows from over the years.

First Hotel Transylvania film where the main antagonist is not a monster that has a strong dislike toward humans.

Kathryn Hahn and Keegan-Michael Key's second movie together, after Tomorrowland (2015), which released in the same year as Hotel Transylvania 2 (2015), which also stars Key.

This is Sony Pictures Animation's 18th feature film.