The interview scenes are based upon the actual interviews with said serial killers, sometimes almost word for word.

The characters of Holden Ford (Jonathan Groff) and Bill Tench (Holt McCallany)are based on real life FBI profilers John Douglas and Robert K. Resslerr. Both agents pioneered the use of criminal profiling in the 1970s.

Based on the true crime book "Mind Hunter: Inside the FBI's Elite Serial Crime Unit", written by John Douglas and Mark Olshaker.

Is shot using a customized, one-of-a-kind version of the RED Epic Dragon built specifically for David Fincher's use, called the "RED Xenomorph".

The show is based on the real-life experiences of John Douglas, a special agent who pioneered the practice of psychological profiling during his 25 years with the FBI.

Charlize Theron and David Fincher had introduced the project to HBO in 2009.

David Fincher approached HBO with the series in 2013. He recalled that they weren't interested in a show about "two white guys in suits" chasing serial killers. The following year, the first season of True Detective (2014) premiered.

In October 2017, Slate reported that Twitter is full of people who mistakenly believe that the actress playing Wendy Carr is Carrie Coon, when in fact Carr is played by Anna Torv. This happened so often that Coon started directly replying to and correcting followers on Twitter who complimented her on her Mindhunter performance, and she also changed her official Twitter bio to read, "That's not me on Mindhunter."

This will be the second Netflix series with David Fincher as a producer. Fincher is a producer for House of Cards (2013).

The character Debbie Mitford, played by Hannah Gross, drives a beige VW Beetle, the same type of car the famous serial killer, Ted Bundy, drove to commit the majority of his murders.

At the end of Season 1 Episode 6, Mindhunter: Episode #1.6 (2017), the show closes with The Boomtown Rats' song, "I Don't Like Mondays" which was written by Bob Geldof after the 1979 mass shooting of 16-year-old Brenda Ann Spencer at Grover Cleveland Elementary in San Diego, CA. The song's title is attributed to Spencer's quoted reason for the shooting: "I don't like Mondays."

A disorder matching the symptoms that Bill Tench's Son allegedly displays is called "selective mutism". Selective mutism is classified as an anxiety disorder that affects up to 0.8% of all people at some point in their lives, most commonly in school and/or social settings.

The prison scenes at Vacaville, CA, where Ed Kemper (Cameron Britton) is interviewed was filmed at the former Pennsylvania State Prison at Greensburg, including the exterior. The scenes with Jerry Brudos (Happy Anderson) were filmed in the same facility, in a cage specially built in the gymnasium.

David Fincher and Holt McCallany have previously worked together on Alien³ (1992) and Fight Club (1999).

The reel to reel tape recorder featured in the opening credits (and later in the series) is based on the Sony TC-510-2. It is not a real recorder, but rather a prop, custom-built to an extremely high standard of finish. The portable cassette recorder later used in season 1 is a Sony TC-D5. The cassette machine used in the Quantico basement office is a Nakamichi 550 portable cassette deck.

In a few scenes taking place outdoors at the FBI Academy in Quantico, VA automatic weapons fire can be heard in the distance. Although this could be agents training it should also be pointed out that Quantico is also an active USMC training facility.

Holden Ford is 29. Bill Tench is 44. In reality, the actors Jonathan Groff and Holt McCallany are 32 and 54, respectively.

While listing off infamous killers they could interview, one of the detective mentions the killer Herbert Mullin, who was actually murdering people at the exact same time and in the exact city (Santa Cruz) as Edmund Kemper, another character in this series. The two of them reigned terror for years, police actually believing that it was only one person doing the killing. When police arrested Mullin after he foolishly shot an old man in the middle of the street in front of multiple witnesses, the police thought they had caught the only killer, until 3 months later when Edmund Kemper confessed.

Anna Torv returns to the FBI in Mindhunter, after portraying FBI agent Olivia Dunham in Fringe (2008).

While Holt McCallany portrays FBI profiler Bill Tench, he previously starred on the other side of the law as an Unsub pursued by the FBI in Criminal Minds (2005).

In Australia, the two historic and most competitive motor company makes are Holden (a General Motors brand) and Ford. The lead character's name is Holden Ford (Jonathan Groff).

Several scenes filmed in Coraopolis, PA, in particular on the 900 block of 7th Avenue.

It was also filmed in the same town as Mothman (Kittanning PA).

Being filmed in Ambridge PA. Also one of the towns featured in Friday Night Tykes Steel Country.

The first Teaser Trailer was released on March 1st, 2017 and announced it wouldn't be released until October, 2017.

For season 2 : There is an active serial killer being alluded to in the series. This is Dennis Rader, better known as The "BTK" Killer, who murdered ten people in Sedgwick County, Kansas between 1974 and 1991.

In one of the final scenes in S1E10, Mindhunter: Episode #1.10 (2017), Ford (Jonathan Groff) meets with Kemper (Cameron Britton) in his hospital room. Kemper stands over Ford and says, "I could kill you now, pretty easily." In reality, a similar interaction took place between Kemper and real-life agent Robert K. Ressler, who inspired the character of Bill Tench (played by Holt McCallany). Kemper, noticing Ressler's nervousness, told him, "If I went apeshit in here, you'd be in a lot of trouble, wouldn't you? I could screw your head off and place it on the table to greet the guard." Ressler shouted at Kemper until a guard arrived and allowed Ressler to leave. Kemper later claimed he was joking.

In one of the later episodes, Dr Wendy Carr (Anna Torv) can be heard asking: "What's in the box"?... possibly a reference to David Fincher's film Se7en (1995) where Brad Pitt's character asks the same question in the famous scene. David Fincher also directed four episodes of the first season of this series.

When Edmund Kemper is telling the story of the night he murdered his mother, his words are nearly exactly the same as an interview filmed and used in the 1984 documentary "Murder: No Apparent Motive", a documentary exploring the still virgin field of criminal/forensic psychology.